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Updated on 26 Apr 2024

SYNAREL Uses, Side Effects, Interactions, Warnings & Dosing

What is SYNAREL?

What is SYNAREL?

SYNAREL is the brand name for nafarelin acetate and is available as a nasal solution.

What dosages is SYNAREL available in?

What dosages is SYNAREL available in?

SYNAREL is available as a 2 mg/ml nasal solution.

What is SYNAREL used for?

What is SYNAREL used for?

SYNAREL is a gonadotropin-releasing hormone (GnRH) agonist that is used to treat endometriosis in adults.

How does SYNAREL work?

How does SYNAREL work?

SYNAREL is a gonadotropin-releasing hormone (GnRH) agonist, meaning that it acts like GnRH. GnRH is a hormone that regulates how much sex hormones gets released into your body. One of these sex hormones is estrogen, which plays a role in endometrial tissue growth. By acting like GnRH, SYNAREL stops the body from releasing estrogen over time. This helps shrink endometrial tissue outside the uterus and relieve pain from endometriosis.

How do I take SYNAREL?

How do I take SYNAREL?

SYNAREL is typically dosed as 1 spray into one nostril in the morning and 1 spray into the other nostril in the evening, separated by about 12 hours. If needed, your provider might raise your dose to 1 spray into each nostril in the morning and evening (a total of 4 sprays per day). You typically start treatment with SYNAREL between days 2 and 4 of your menstrual cycle. The recommended length of treatment is 6 months.

Is it safe for me to take SYNAREL?

Is it safe for me to take SYNAREL?

SYNAREL is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • Hypersensitivity to GnRH, GnRH agonist analogs or any of the excipients in SYNAREL
  • Undiagnosed abnormal vaginal bleeding
  • Use in pregnancy or in women who may become pregnant while receiving the drug
SYNAREL Common Side Effects

SYNAREL Common Side Effects

Common side effects of SYNAREL:

  • Hot flashes
  • Lower sex drive
  • Vaginal dryness
  • Headaches
  • Mood swings
  • Acne
SYNAREL Serious Side Effects

SYNAREL Serious Side Effects

Serious side effects are rare with SYNAREL.

Effects of other drugs, drug classes and over-the-counter products on SYNAREL

Effects of other drugs, drug classes and over-the-counter products on SYNAREL

The following medications may interact with SYNAREL:


Who makes SYNAREL?

Who makes SYNAREL?


Is SYNAREL safe in pregnancy?

Is SYNAREL safe in pregnancy?

No pharmacokinetic-based drug-drug interaction studies have been conducted with SYNAREL. Tell your healthcare provider right away if you are or if you become pregnant.


What to do if you missed your SYNAREL dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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