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MEDICAL INFORMATION
Synarel Key Facts
What is Synarel?
Synarel is the brand name for nafarelin acetate and is available as a nasal solution.
What dosages is Synarel available in?
Synarel is available as a 2 mg/ml nasal solution.
What is Synarel used for?
Synarel is a gonadotropin-releasing hormone (GnRH) agonist that is used to treat endometriosis in adults.
How does Synarel work?
Synarel is a gonadotropin-releasing hormone (GnRH) agonist, meaning that it acts like GnRH. GnRH is a hormone that regulates how much sex hormones gets released into your body. One of these sex hormones is estrogen, which plays a role in endometrial tissue growth. By acting like GnRH, Synarel stops the body from releasing estrogen over time. This helps shrink endometrial tissue outside the uterus and relieve pain from endometriosis.
How do I take Synarel?
Synarel is typically dosed as 1 spray into one nostril in the morning and 1 spray into the other nostril in the evening, separated by about 12 hours. If needed, your provider might raise your dose to 1 spray into each nostril in the morning and evening (a total of 4 sprays per day). You typically start treatment with Synarel between days 2 and 4 of your menstrual cycle. The recommended length of treatment is 6 months.
Is it safe for me to take Synarel?
Synarel is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Hypersensitivity to GnRH, GnRH agonist analogs or any of the excipients in Synarel
- Undiagnosed abnormal vaginal bleeding
- Use in pregnancy or in women who may become pregnant while receiving the drug
Synarel Common Side Effects
Common side effects of Synarel:
- Hot flashes
- Lower sex drive
- Vaginal dryness
- Headaches
- Mood swings
- Acne
Synarel Serious Side Effects
Serious side effects are rare with Synarel.
Effects of other drugs, drug classes and over-the-counter products on Synarel
The following medications may interact with Synarel:
Who makes Synarel?
Pfizer
Is Synarel safe in pregnancy?
No pharmacokinetic-based drug-drug interaction studies have been conducted with Synarel. Tell your healthcare provider right away if you are or if you become pregnant.
What is the generic name for Synarel?
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
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We are a broad skilled and passionate group of clinicians with experience of operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process
Navin Khosla
UK Responsible Person (UKRP), Pharmacist Independent Prescriber, Clinical Safety Officer (CSO), Pharmacist
Ketan Patel
Pharmacist Independent Prescriber, Pharmacist
Rajive Patel
Medical Writer
Stefano Mirabello
Pharmacist Independent Prescriber, Clinical Safety Officer (CSO), Pharmacist
DeLon Canterbury
US Board Certified Pharmacist/PGX & Deprescribing Specialist
Jamie Winn
US Board Certified Pharmacist
Ihtesham Sabri
Medical Director
Daniel Cheung
Pharmacist Independent Prescriber, Pharmacist
Amish Patel
Pharmacist Independent Prescriber, Superintendant Pharmacist, Pharmacist
Monica Khosla
Medical Writer
Aseel Hamoud Bedan
Hospital Consultant