View SYMMETREL savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or SYMMETREL Patient Assistance Program.

Programs are suitable for individuals who want to buy SYMMETREL without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Endo Pharmaceuticals

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about SYMMETREL



SYMMETREL is the brand name for amantadine and is available as an oral tablet, capsule, and syrup.

What dosages is SYMMETREL available in?

What dosages is SYMMETREL available in?

SYMMETREL is available as a 100 mg oral tablet/capsule and a 50 mg/5 ml oral syrup.

What is SYMMETREL used for?

What is SYMMETREL used for?

SYMMETREL is a NMDA antagonist and is used to treat the following:

  • Parkinsonism, including Parkinson’s disease (PD)
  • Extrapyramidal symptoms (uncontrolled body movements)
How does SYMMETREL work?

How does SYMMETREL work?

SYMMETREL is an N-methyl-D-aspartate (NMDA) antagonist. The way it treats Parkinson’s disease isn’t well-understood. But it’s thought to work by blocking NMDA receptor in the brain, which raises dopamine levels. This helps to relieve some movement symptoms, such as trembling, stiffness, and slowness of movement.

How do I take SYMMETREL?

How do I take SYMMETREL?

SYMMETREL is dosed as follows:

  • Parkinsonism, including Parkinson’s disease: The typical starting dose is 100 mg by mouth once daily. If needed, your provider might raise your dose to 100 mg twice daily. The maximum total dose is 400 mg daily, taken in divided doses
  • Extrapyramidal symptoms: The typical starting dose is 100 mg by mouth twice daily. The maximum total dose is 300 mg daily, taken in divided doses
  • Your dose might differ if you’ve kidney problems
Is it safe for me to take SYMMETREL?

Is it safe for me to take SYMMETREL?

SYMMETREL is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

SYMMETREL Common Side Effects

SYMMETREL Common Side Effects

Common side effects of SYMMETREL:

  • Nausea
  • Dizziness
  • Trouble sleeping
SYMMETREL Serious Side Effects

SYMMETREL Serious Side Effects

Serious side effects are rare with SYMMETREL. Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or behaviors
  • Neuroleptic malignant syndrome (NMS): very high fevers, irregular pulse, sweating, muscle stiffness, confusion, changes in blood pressure
  • Accidentally taking too much (overdose): death, fast heartbeat, difficulty breathing, decreased urination, stiff or rigid arms or legs, confusion
Effects of other drugs, drug classes and over-the-counter products on SYMMETREL

Effects of other drugs, drug classes and over-the-counter products on SYMMETREL

The following medications may interact with SYMMETREL:

  • Careful observation is required when SYMMETREL is administered concurrently with central nervous system stimulants
  • Agents with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine
  • Coadministration of thioridazine has been reported to worsen the tremor in elderly patients with Parkinson’s disease
  • Coadministration of quinine or quinidine with amantadine was shown to reduce the renalclearance of amantadine by about 30%
  • The concurrent use of SYMMETREL with live attenuated influenza vaccine (LAIV) intranasal has not been evaluated. However, because of the potential for interference between these products, LAIV should not be administered within 2 weeks before or 48 hours after administration of SYMMETREL, unless medically indicated
  • Trivalent inactivated influenza vaccine can be administered at any time relative to use of SYMMETREL
Who makes SYMMETREL?

Who makes SYMMETREL?

Endo Pharmaceuticals

Is SYMMETREL safe in pregnancy?

Is SYMMETREL safe in pregnancy?

There are no adequate and well-controlled studies of SYMMETREL in pregnant women. It is unknown whether SYMMETREL can cause fetal harm when administered to a pregnant woman. SYMMETREL should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.


What to do if you missed your SYMMETREL dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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