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MEDICAL INFORMATION
Symmetrel Key Facts
What is Symmetrel?
Symmetrel is the brand name for amantadine and is available as an oral tablet, capsule, and syrup.
What dosages is Symmetrel available in?
Symmetrel is available as a 100 mg oral tablet/capsule and a 50 mg/5 ml oral syrup.
What is Symmetrel used for?
Symmetrel is a NMDA antagonist and is used to treat the following:
- Parkinsonism, including Parkinson’s disease (PD)
- Extrapyramidal symptoms (uncontrolled body movements)
How does Symmetrel work?
Symmetrel is an N-methyl-D-aspartate (NMDA) antagonist. The way it treats Parkinson’s disease isn’t well-understood. But it’s thought to work by blocking NMDA receptor in the brain, which raises dopamine levels. This helps to relieve some movement symptoms, such as trembling, stiffness, and slowness of movement.
How do I take Symmetrel?
Symmetrel is dosed as follows:
- Parkinsonism, including Parkinson’s disease: The typical starting dose is 100 mg by mouth once daily. If needed, your provider might raise your dose to 100 mg twice daily. The maximum total dose is 400 mg daily, taken in divided doses
- Extrapyramidal symptoms: The typical starting dose is 100 mg by mouth twice daily. The maximum total dose is 300 mg daily, taken in divided doses
- Your dose might differ if you’ve kidney problems
Is it safe for me to take Symmetrel?
Symmetrel is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
Symmetrel Common Side Effects
Common side effects of Symmetrel:
- Nausea
- Dizziness
- Trouble sleeping
Symmetrel Serious Side Effects
Serious side effects are rare with Symmetrel. Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts or behaviors
- Neuroleptic malignant syndrome (NMS): very high fevers, irregular pulse, sweating, muscle stiffness, confusion, changes in blood pressure
- Accidentally taking too much (overdose): death, fast heartbeat, difficulty breathing, decreased urination, stiff or rigid arms or legs, confusion
Effects of other drugs, drug classes and over-the-counter products on Symmetrel
The following medications may interact with Symmetrel:
- Careful observation is required when Symmetrel is administered concurrently with central nervous system stimulants
- Agents with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine
- Coadministration of thioridazine has been reported to worsen the tremor in elderly patients with Parkinson’s disease
- Coadministration of quinine or quinidine with amantadine was shown to reduce the renalclearance of amantadine by about 30%
- The concurrent use of Symmetrel with live attenuated influenza vaccine (LAIV) intranasal has not been evaluated. However, because of the potential for interference between these products, LAIV should not be administered within 2 weeks before or 48 hours after administration of Symmetrel, unless medically indicated
- Trivalent inactivated influenza vaccine can be administered at any time relative to use of Symmetrel
Who makes Symmetrel?
Endo Pharmaceuticals
Is Symmetrel safe in pregnancy?
There are no adequate and well-controlled studies of Symmetrel in pregnant women. It is unknown whether Symmetrel can cause fetal harm when administered to a pregnant woman. Symmetrel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
What is the generic name for Symmetrel?
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
HOW IT WORKS
Order Delivery Guide


How will my order be delivered?
All orders are shipped in discreet and unmarked packaging, making them suitable for delivery to your home, workplace, or a neighbour. For your protection and safety, your first order can only be delivered to the address that is registered with NowPatient. Future orders can be delivered to any address you choose.
Where does NowPatient deliver?
NowPatient delivers to the UK, Europe, and worldwide. NHS services (such as NHS Online Pharmacy and NHS Pharmacy First) are available to patients in England only. Our private services and online pharmacy are available across the UK, with international shipping available to European and worldwide addresses. Please note that some remote or rural postcodes may experience slightly longer delivery times, and tracking availability for worldwide orders may vary depending on the destination country.
What delivery options are available?
UK orders are shipped via Royal Mail Tracked 24 & Signed, with next-day delivery as standard. European deliveries are sent via Royal Mail Tracked and typically arrive within 3–5 working days. Worldwide deliveries take 7–21 working days and are tracked where available in the destination country.
Delivery charges apply for most services. Shipping is included in the price for patients using our Get Treated Privately service in England, and is free for NHS Quit Smoking Service orders.
When will my order be dispatched?
We aim to dispatch all orders placed Monday to Friday before 3:00pm on the same working day. Orders placed after 3:00pm, or over weekends and bank holidays, will be dispatched on the next available working day.
Do you offer next-day delivery?
Yes. All UK orders are shipped via Royal Mail Tracked 24 & Signed, which delivers next day as standard. To qualify for same-day dispatch, please place your order before 3:00pm Monday to Friday. Orders placed after this time, or over weekends and bank holidays, will be dispatched on the next available working day.
Do you deliver temperature-sensitive or cold-chain medications?
Yes. We use a specialist courier service for all thermo-sensitive deliveries (such as insulin, GLP-1 weight loss injections like Mounjaro, and other refrigerated medications). Cold chain-validated packaging is used throughout the entire delivery process to ensure product quality, safety, and efficacy are always maintained.
How is cold-chain packaging handled?
Temperature-sensitive products are packed using validated cold chain packaging that maintains the required storage temperature throughout transit. Your parcel will normally receive an estimated delivery window from the courier on the day of delivery, so you can ensure someone is available to receive it. If you have concerns about receiving a cold-chain delivery, please contact our customer care team in advance.
Do you deliver controlled drugs?
Yes. Controlled drugs are delivered using a specialist courier service to ensure secure and compliant handling in accordance with UK regulations. These deliveries will always require a signature upon receipt.
How do I track my order?
Once your order has been dispatched, you will receive a dispatch notification containing your tracking details. You can also view your tracking information at any time in the 'Notification Feed' section on your account dashboard. Tracking is available for all delivery options.
Will I receive status updates about my order?
Yes. NowPatient uses a structured notification system to keep you fully informed throughout the order process. Every time your order status changes — from approval through to dispatch and delivery — you will be notified immediately. Notifications are sent via email and appear in the 'Notifications' section of your account homepage (accessible via the bell icon). This includes updates when your treatment is approved, dispensed, and shipped.
What order statuses will I see?
You can expect to see the following key status updates: Order Received, Prescription Approved (where applicable), Order Dispensed, Dispatched (with tracking reference), and Delivered.
Can I change my delivery address?
For your first order, delivery must be made to the address registered with NowPatient at the time of sign-up. This is a safety measure to verify your identity and protect your account. From your second order onwards, you can select from any saved address in your account or add a new delivery address during checkout.
Can I have my order delivered to my workplace or a neighbour?
Yes. From your second order onwards, you can have your medication delivered to any address, including your workplace, a family member's address, or a neighbour. All parcels are sent in discreet, unmarked packaging, so the contents will not be identifiable.
How do I update or add a new delivery address?
You can manage your delivery addresses directly within your NowPatient account settings. Additional addresses can also be added during the checkout process when selecting your delivery address. Simply select 'Add a new address' and enter the required details.
What should I do if my order hasn't arrived?
If you have not received your order within the expected delivery window, please first check your tracking details in the 'Notification Feed' section of your account dashboard. If after 10 days of dispatch you have still not received your delivery, please contact our customer care team and we will work to resolve the issue as quickly as possible.
What if my order arrives damaged?
If your order arrives in a damaged condition, please do not use the medication and contact our customer care team immediately. Please retain the original packaging and, if possible, take photographs of the damage, as this will help us raise a claim with the courier and arrange a replacement for you as quickly as possible.
My tracking shows delivered but I haven't received my parcel — what should I do?
First, check with any neighbours or safe locations at your property (such as a porch or outbuilding). If you still cannot locate your parcel, please contact our customer care team and we will investigate the matter with the courier on your behalf.
What happens if I miss my delivery?
If you miss a delivery, the courier will typically leave a card with instructions for rescheduling or collecting your parcel from a local depot. For cold-chain deliveries, it is particularly important to arrange redelivery promptly to maintain product integrity. If you have concerns about a missed cold-chain delivery, please contact our customer care team for guidance.
If you ship international, do I need to handle duties?
No. Our prices include customs duties, wherever you are located.
How are NHS repeat prescriptions delivered?
Once your GP has approved your prescription request, NowPatient's regulated online pharmacy will dispense and dispatch your medication. You will be notified at each stage of the process. NHS prescriptions are dispatched via Royal Mail Tracked 24 & Signed for next-day delivery, provided the order is placed before 3:00pm on a
working day.
Is delivery free for NHS prescriptions?
No. There is a small cost applied to all NHS prescription deliveries. This allows us to keep our service operational. NHS Quit Smoking Service orders qualify for free delivery. If you are using the Get Treated Privately service in England, shipping is included within the consultation and treatment price.
Can I specify a preferred delivery date for my NHS prescription?
At this time, NowPatient dispatches orders on the same working day if placed before 3:00pm Monday to Friday. All UK NHS prescriptions are sent via Royal Mail Tracked 24 & Signed for next-day delivery, so you can plan accordingly once you receive your dispatch notification.
How are private prescription medications delivered after a telehealth consultation?
Following your telehealth or video consultation, if a treatment is prescribed, it will be added to your cart automatically. After you complete checkout and payment, your order is sent to NowPatient's regulated online pharmacy for processing. You will receive status updates at every stage and your medication will be dispatched in discreet, unmarked packaging.
How quickly will I receive medication after my consultation?
If your consultation and checkout are completed before 3:00pm on a working day, we aim to dispatch your medication the same day. The total time to delivery will depend on the delivery method you select at checkout.
Is the packaging discreet?
Yes. All NowPatient orders are shipped in plain, unmarked packaging with no branding or indication of the contents on the outside. The packaging is suitable for delivery to your home, workplace, or a neighbour.
Will my parcel require a signature?
Yes. All UK orders are sent via Royal Mail Tracked 24 & Signed, which requires a signature upon delivery. Controlled drug deliveries will always require a signature regardless of the shipping method. For cold-chain deliveries, a signature is required to ensure someone is available to receive the medication promptly and maintain product integrity. For European and worldwide orders, signature requirements may vary depending on the destination country and the service available.
How do I contact NowPatient about a delivery issue?
You can reach our customer care team through the NowPatient website or app. Go to your account and use the Help or Contact Us section to raise a query. Our team is available to assist with any delivery-related concerns including missing parcels, tracking queries, or delivery address changes.
What are NowPatient's customer care hours?
Please visit the Contact Us section of the NowPatient website or app for up-to-date information on our customer care operating hours and available contact methods.
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Medicines Experts
Meet Our Medical Team
We are a broad skilled and passionate group of clinicians with experience of operating in regulated health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process


























