SYMMETREL
Are you tired of high medication costs? Our service offers unbeatable savings on your SYMMETREL prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Endo Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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Lower the cost of your SYMMETREL prescription
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SYMMETREL key facts
What is SYMMETREL?
SYMMETREL is the brand name for amantadine and is available as an oral tablet, capsule, and syrup.
What dosages is SYMMETREL available in?
SYMMETREL is available as a 100 mg oral tablet/capsule and a 50 mg/5 ml oral syrup.
What is SYMMETREL used for?
SYMMETREL is a NMDA antagonist and is used to treat the following:
- Parkinsonism, including Parkinson’s disease (PD)
- Extrapyramidal symptoms (uncontrolled body movements)
How does SYMMETREL work?
SYMMETREL is an N-methyl-D-aspartate (NMDA) antagonist. The way it treats Parkinson’s disease isn’t well-understood. But it’s thought to work by blocking NMDA receptor in the brain, which raises dopamine levels. This helps to relieve some movement symptoms, such as trembling, stiffness, and slowness of movement.
How do I take SYMMETREL?
SYMMETREL is dosed as follows:
- Parkinsonism, including Parkinson’s disease: The typical starting dose is 100 mg by mouth once daily. If needed, your provider might raise your dose to 100 mg twice daily. The maximum total dose is 400 mg daily, taken in divided doses
- Extrapyramidal symptoms: The typical starting dose is 100 mg by mouth twice daily. The maximum total dose is 300 mg daily, taken in divided doses
- Your dose might differ if you’ve kidney problems
Is it safe for me to take SYMMETREL?
SYMMETREL is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
SYMMETREL Common Side Effects
Common side effects of SYMMETREL:
- Nausea
- Dizziness
- Trouble sleeping
SYMMETREL Serious Side Effects
Serious side effects are rare with SYMMETREL. Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts or behaviors
- Neuroleptic malignant syndrome (NMS): very high fevers, irregular pulse, sweating, muscle stiffness, confusion, changes in blood pressure
- Accidentally taking too much (overdose): death, fast heartbeat, difficulty breathing, decreased urination, stiff or rigid arms or legs, confusion
Effects of other drugs, drug classes and over-the-counter products on SYMMETREL
The following medications may interact with SYMMETREL:
- Careful observation is required when SYMMETREL is administered concurrently with central nervous system stimulants
- Agents with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine
- Coadministration of thioridazine has been reported to worsen the tremor in elderly patients with Parkinson’s disease
- Coadministration of quinine or quinidine with amantadine was shown to reduce the renalclearance of amantadine by about 30%
- The concurrent use of SYMMETREL with live attenuated influenza vaccine (LAIV) intranasal has not been evaluated. However, because of the potential for interference between these products, LAIV should not be administered within 2 weeks before or 48 hours after administration of SYMMETREL, unless medically indicated
- Trivalent inactivated influenza vaccine can be administered at any time relative to use of SYMMETREL
Who makes SYMMETREL?
Endo Pharmaceuticals
Is SYMMETREL safe in pregnancy?
There are no adequate and well-controlled studies of SYMMETREL in pregnant women. It is unknown whether SYMMETREL can cause fetal harm when administered to a pregnant woman. SYMMETREL should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my SYMMETREL prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your SYMMETREL prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient SYMMETREL savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient SYMMETREL savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for SYMMETREL | Canadian Prescription Savings* for SYMMETREL | SYMMETREL Drug Coupon* | SYMMETREL Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of SYMMETREL?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for SYMMETREL | Canadian Prescription Savings* for SYMMETREL | SYMMETREL Drug Coupon* | SYMMETREL Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the SYMMETREL savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the SYMMETREL drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for SYMMETREL, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the SYMMETREL prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, SYMMETREL is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed SYMMETREL for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the SYMMETREL prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the SYMMETREL prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for SYMMETREL
If you are having trouble paying for your SYMMETREL medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for SYMMETREL you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- SYMMETREL is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers SYMMETREL
- If SYMMETREL is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for SYMMETREL
If you are having trouble paying for your SYMMETREL medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for SYMMETREL you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers SYMMETREL
- If SYMMETREL is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for SYMMETREL
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your SYMMETREL treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for SYMMETREL you will need to meet the following criteria:
- You must be currently insured and have coverage for SYMMETREL
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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NowPatient is owned and operated by Infohealth Ltd, a licensed online pharmacy with services spanning the UK, US and Rest of the World. Infohealth Ltd is registered in England and Wales under company number 04004930 and our registered office is at Lynwood House, 373 – 375 Station Road, Harrow, England, HA1 2AW.
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Our dispensing pharmacy is regulated and authorized for internet sales by the General Pharmaceutical Council (GPhC), registration number 1036487. You can view our license credentials on the General Pharmaceutical Council website. Our superintendent pharmacist who is responsible for the safe and effective oversight of medicines supplies is Mr Amish Patel (Registration Number 2042705).
Medicines are not ordinary items of commerce. All medicines or healthcare product sales are made under the supervision of a registered pharmacist who is licensed by the GPhC. At all times, we endeavour to provide a professional and transparent service whose primary goal is to ensure that the best interests of the patient are served.
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Our head of US services is Dr. Jamie Winn.
You can lower the cost of your prescription medications using our various savings programs which include drug coupons, savings card and manufacturer-sponsored patient assistance programs.
We do not provide any prescribing services or dispensing services in the United States.
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