STALEVO
Used for Parkinson’s Disease
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Manufactured by Orion Pharma
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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STALEVO key facts
What is STALEVO?
STALEVO is the brand name for carbidopa, levodopa and entacapone and is available as an oral tablet.
What dosages is STALEVO available in?
STALEVO is available as STALEVO 50 (12.5 mg per 50 mg per 200 mg), STALEVO 75 (18.75 mg per 75 mg per 200 mg), STALEVO 100 (25 mg per 100 mg per 200 mg), STALEVO 125 (31.25 mg per 125 mg per 200 mg), STALEVO 150 (37.5 mg per 150 mg per 200 mg), and STALEVO 200 (50 mg per 200 mg per 200 mg) oral tablets.
What is STALEVO used for?
STALEVO is a dopa decarboxylase inhibitor / dopamine replacement / COMT inhibitor and is used to treat Parkinson’s disease (PD).
How does STALEVO work?
STALEVO is a combination of three medications: carbidopa, levodopa, and entacapone. By working together, these medications help relieve symptoms of Parkinson’s disease (PD), which occur due to low dopamine levels in the brain. Levodopa is a dopamine replacement.
Levodopa travels into your brain, where it’s converted into dopamine. It helps relieve PD symptoms by restoring dopamine in your brain. Carbidopa is a dopa decarboxylase inhibitor and entacapone is a catechol-O-methyltransferase (COMT) inhibitor.
Dopa decarboxylase and COMT are proteins in your body that break down levodopa before it can travel into your brain. By blocking these proteins, carbidopa and entacapone prevent levodopa from breaking down.
This raises the level of levodopa in your body and allows more levodopa to travel into your brain to be converted into dopamine. Levodopa and dopamine can then reach and remain at higher levels in your brain, which enhances the medications’ ability to relieve PD symptoms.
How do I take STALEVO?
STALEVO is dosed on your response to your previous medication regimen for PD.
For people previously taking Sinemet (carbidopa / levodopa) tablets plus an entacapone (Comtan) tablet: The dose will typically stay the same. You can switch directly to the combination tablet that contains the same amount of carbidopa, levodopa, and entacapone.
For people previously taking Sinemet (carbidopa / levodopa) tablets alone: You will typically start taking entacapone (Comtan) tablets along with your Sinemet (carbidopa / levodopa) tablets. Your provider will slowly adjust your dose until your PD symptoms are controlled. Once they find a dose that works for you, they will prescribe a Stalevo tablet that matches this dose.
Is it safe for me to take STALEVO?
STALEVO is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a nonselective monoamine oxidase (MAO) inhibitor or have narrow-angle glaucoma.
STALEVO Common Side Effects
Common side effects of STALEVO:
- Involuntary movements
- Nausea
- Muscle spasms
- Diarrhea
- Changes in the color of your urine
- Slow muscle movement
- Stomach pain
- Dizziness
- Vomiting
- Dry mouth
STALEVO Serious Side Effects
Serious side effects are rare with STALEVO. Contact your healthcare provider immediately if you experience any of the following.
- Neuroleptic malignant syndrome (NMS): very high fevers, confusion, irregular pulse, sweating, muscle stiffness, changes in blood pressure
- Severe muscle damage (rhabdomyolysis): muscle aches, soreness, cramping, dark-colored urine
Effects of other drugs, drug classes and over-the-counter products on STALEVO
The following medications may interact with STALEVO:
- Drugs metabolized by COMT: use with caution.
- Anti-hypertensive agents: dose adjustment may be required
- Tricyclic antidepressants: risk of hypertension and dyskinesia reported
- during concomitant use with carbidopa/levodopa.
- Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of STALEVO
- Drugs that interfere with biliary excretion, glucuronidation and intestinal beta-glucuronidase: dose adjustment of STALEVO may be required
- Drugs metabolized by CYP2C9 (e.g., coumadin): dose adjustment of STALEVO may be required; monitor INR when initiating STALEVO in patients on coumadin
Who makes STALEVO?
Orion Pharma
Is STALEVO safe in pregnancy?
Based on animal data, STALEVO may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant. STALEVO should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my STALEVO prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your STALEVO prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient STALEVO savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient STALEVO savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for STALEVO | Canadian Prescription Savings* for STALEVO | STALEVO Drug Coupon* | STALEVO Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of STALEVO?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for STALEVO | Canadian Prescription Savings* for STALEVO | STALEVO Drug Coupon* | STALEVO Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the STALEVO savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the STALEVO drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for STALEVO, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the STALEVO prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, STALEVO is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed STALEVO for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the STALEVO prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the STALEVO prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for STALEVO
If you are having trouble paying for your STALEVO medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for STALEVO you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- STALEVO is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers STALEVO
- If STALEVO is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for STALEVO
If you are having trouble paying for your STALEVO medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for STALEVO you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers STALEVO
- If STALEVO is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for STALEVO
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your STALEVO treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for STALEVO you will need to meet the following criteria:
- You must be currently insured and have coverage for STALEVO
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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