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Programs are suitable for individuals who want to buy carbidopa/levodopa/entacapone without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by various FDA-approved generic manufacturers.

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Updated on 24 Apr 2024

Learn more about carbidopa/levodopa/entacapone

What dosages is carbidopa/levodopa/entacapone available in?

What dosages is carbidopa/levodopa/entacapone available in?

carbidopa/levodopa/entacapone is available as carbidopa/levodopa/entacapone 50 (12.5 mg per 50 mg per 200 mg), carbidopa/levodopa/entacapone 75 (18.75 mg per 75 mg per 200 mg), carbidopa/levodopa/entacapone 100 (25 mg per 100 mg per 200 mg), carbidopa/levodopa/entacapone 125 (31.25 mg per 125 mg per 200 mg), carbidopa/levodopa/entacapone 150 (37.5 mg per 150 mg per 200 mg), and carbidopa/levodopa/entacapone 200 (50 mg per 200 mg per 200 mg) oral tablets.

What is carbidopa/levodopa/entacapone used for?

What is carbidopa/levodopa/entacapone used for?

carbidopa/levodopa/entacapone is a dopa decarboxylase inhibitor / dopamine replacement / COMT inhibitor and is used to treat Parkinson’s disease (PD).

How does carbidopa/levodopa/entacapone work?

How does carbidopa/levodopa/entacapone work?

carbidopa/levodopa/entacapone is a combination of three medications: carbidopa, levodopa, and entacapone. By working together, these medications help relieve symptoms of Parkinson’s disease (PD), which occur due to low dopamine levels in the brain. Levodopa is a dopamine replacement.

Levodopa travels into your brain, where it’s converted into dopamine. It helps relieve PD symptoms by restoring dopamine in your brain. Carbidopa is a dopa decarboxylase inhibitor and entacapone is a catechol-O-methyltransferase (COMT) inhibitor.

Dopa decarboxylase and COMT are proteins in your body that break down levodopa before it can travel into your brain. By blocking these proteins, carbidopa and entacapone prevent levodopa from breaking down.

This raises the level of levodopa in your body and allows more levodopa to travel into your brain to be converted into dopamine. Levodopa and dopamine can then reach and remain at higher levels in your brain, which enhances the medications’ ability to relieve PD symptoms.

How do I take carbidopa/levodopa/entacapone?

How do I take carbidopa/levodopa/entacapone?

carbidopa/levodopa/entacapone is dosed on your response to your previous medication regimen for PD.

For people previously taking Sinemet (carbidopa / levodopa) tablets plus an entacapone (Comtan) tablet: The dose will typically stay the same. You can switch directly to the combination tablet that contains the same amount of carbidopa, levodopa, and entacapone.

For people previously taking Sinemet (carbidopa / levodopa) tablets alone: You will typically start taking entacapone (Comtan) tablets along with your Sinemet (carbidopa / levodopa) tablets. Your provider will slowly adjust your dose until your PD symptoms are controlled. Once they find a dose that works for you, they will prescribe a carbidopa/levodopa/entacapone tablet that matches this dose.

Is it safe for me to take carbidopa/levodopa/entacapone?

Is it safe for me to take carbidopa/levodopa/entacapone?

carbidopa/levodopa/entacapone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a nonselective monoamine oxidase (MAO) inhibitor or have narrow-angle glaucoma.

carbidopa/levodopa/entacapone Common Side Effects

carbidopa/levodopa/entacapone Common Side Effects

Common side effects of carbidopa/levodopa/entacapone:

  • Involuntary movements
  • Nausea
  • Muscle spasms
  • Diarrhea
  • Changes in the color of your urine
  • Slow muscle movement
  • Stomach pain
  • Dizziness
  • Vomiting
  • Dry mouth
carbidopa/levodopa/entacapone Serious Side Effects

carbidopa/levodopa/entacapone Serious Side Effects

Serious side effects are rare with carbidopa/levodopa/entacapone. Contact your healthcare provider immediately if you experience any of the following.

  • Neuroleptic malignant syndrome (NMS): very high fevers, confusion, irregular pulse, sweating, muscle stiffness, changes in blood pressure
  • Severe muscle damage (rhabdomyolysis): muscle aches, soreness, cramping, dark-colored urine
Effects of other drugs, drug classes and over-the-counter products on carbidopa/levodopa/entacapone

Effects of other drugs, drug classes and over-the-counter products on carbidopa/levodopa/entacapone

The following medications may interact with carbidopa/levodopa/entacapone:

  • Drugs metabolized by COMT: use with caution.
  • Anti-hypertensive agents: dose adjustment may be required
  • Tricyclic antidepressants: risk of hypertension and dyskinesia reported
  • during concomitant use with carbidopa/levodopa.
  • Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa/levodopa/entacapone
  • Drugs that interfere with biliary excretion, glucuronidation and intestinal beta-glucuronidase: dose adjustment of carbidopa/levodopa/entacapone may be required
  • Drugs metabolized by CYP2C9 (e.g., coumadin): dose adjustment of carbidopa/levodopa/entacapone may be required; monitor INR when initiating carbidopa/levodopa/entacapone in patients on coumadin
Who makes carbidopa/levodopa/entacapone?

Who makes carbidopa/levodopa/entacapone?

Various FDA-approved generic manufacturers

Is carbidopa/levodopa/entacapone safe in pregnancy?

Is carbidopa/levodopa/entacapone safe in pregnancy?

Based on animal data, carbidopa/levodopa/entacapone may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant. carbidopa/levodopa/entacapone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.


What to do if you missed your carbidopa/levodopa/entacapone dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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