carbidopa/levodopa/entacapone
Used for Parkinson’s Disease
NowPatient can significantly lower the cost* of your prescription medication by providing free access to drug coupons, savings cards, patient assistance programs and other out of pocket discount programs. Whether you’re insured, uninsured, or underinsured, we empower you with transparency and cost-saving tools to make your carbidopa/levodopa/entacapone more affordable.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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carbidopa/levodopa/entacapone key facts
What dosages is carbidopa/levodopa/entacapone available in?
carbidopa/levodopa/entacapone is available as carbidopa/levodopa/entacapone 50 (12.5 mg per 50 mg per 200 mg), carbidopa/levodopa/entacapone 75 (18.75 mg per 75 mg per 200 mg), carbidopa/levodopa/entacapone 100 (25 mg per 100 mg per 200 mg), carbidopa/levodopa/entacapone 125 (31.25 mg per 125 mg per 200 mg), carbidopa/levodopa/entacapone 150 (37.5 mg per 150 mg per 200 mg), and carbidopa/levodopa/entacapone 200 (50 mg per 200 mg per 200 mg) oral tablets.
What is carbidopa/levodopa/entacapone used for?
carbidopa/levodopa/entacapone is a dopa decarboxylase inhibitor / dopamine replacement / COMT inhibitor and is used to treat Parkinson’s disease (PD).
How does carbidopa/levodopa/entacapone work?
carbidopa/levodopa/entacapone is a combination of three medications: carbidopa, levodopa, and entacapone. By working together, these medications help relieve symptoms of Parkinson’s disease (PD), which occur due to low dopamine levels in the brain. Levodopa is a dopamine replacement.
Levodopa travels into your brain, where it’s converted into dopamine. It helps relieve PD symptoms by restoring dopamine in your brain. Carbidopa is a dopa decarboxylase inhibitor and entacapone is a catechol-O-methyltransferase (COMT) inhibitor.
Dopa decarboxylase and COMT are proteins in your body that break down levodopa before it can travel into your brain. By blocking these proteins, carbidopa and entacapone prevent levodopa from breaking down.
This raises the level of levodopa in your body and allows more levodopa to travel into your brain to be converted into dopamine. Levodopa and dopamine can then reach and remain at higher levels in your brain, which enhances the medications’ ability to relieve PD symptoms.
How do I take carbidopa/levodopa/entacapone?
carbidopa/levodopa/entacapone is dosed on your response to your previous medication regimen for PD.
For people previously taking Sinemet (carbidopa / levodopa) tablets plus an entacapone (Comtan) tablet: The dose will typically stay the same. You can switch directly to the combination tablet that contains the same amount of carbidopa, levodopa, and entacapone.
For people previously taking Sinemet (carbidopa / levodopa) tablets alone: You will typically start taking entacapone (Comtan) tablets along with your Sinemet (carbidopa / levodopa) tablets. Your provider will slowly adjust your dose until your PD symptoms are controlled. Once they find a dose that works for you, they will prescribe a carbidopa/levodopa/entacapone tablet that matches this dose.
Is it safe for me to take carbidopa/levodopa/entacapone?
carbidopa/levodopa/entacapone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a nonselective monoamine oxidase (MAO) inhibitor or have narrow-angle glaucoma.
carbidopa/levodopa/entacapone Common Side Effects
Common side effects of carbidopa/levodopa/entacapone:
- Involuntary movements
- Nausea
- Muscle spasms
- Diarrhea
- Changes in the color of your urine
- Slow muscle movement
- Stomach pain
- Dizziness
- Vomiting
- Dry mouth
carbidopa/levodopa/entacapone Serious Side Effects
Serious side effects are rare with carbidopa/levodopa/entacapone. Contact your healthcare provider immediately if you experience any of the following.
- Neuroleptic malignant syndrome (NMS): very high fevers, confusion, irregular pulse, sweating, muscle stiffness, changes in blood pressure
- Severe muscle damage (rhabdomyolysis): muscle aches, soreness, cramping, dark-colored urine
Effects of other drugs, drug classes and over-the-counter products on carbidopa/levodopa/entacapone
The following medications may interact with carbidopa/levodopa/entacapone:
- Drugs metabolized by COMT: use with caution.
- Anti-hypertensive agents: dose adjustment may be required
- Tricyclic antidepressants: risk of hypertension and dyskinesia reported
- during concomitant use with carbidopa/levodopa.
- Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa/levodopa/entacapone
- Drugs that interfere with biliary excretion, glucuronidation and intestinal beta-glucuronidase: dose adjustment of carbidopa/levodopa/entacapone may be required
- Drugs metabolized by CYP2C9 (e.g., coumadin): dose adjustment of carbidopa/levodopa/entacapone may be required; monitor INR when initiating carbidopa/levodopa/entacapone in patients on coumadin
Who makes carbidopa/levodopa/entacapone?
Various FDA-approved generic manufacturers
Is carbidopa/levodopa/entacapone safe in pregnancy?
Based on animal data, carbidopa/levodopa/entacapone may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant. carbidopa/levodopa/entacapone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription drug costs
How can NowPatient help me to lower the cost of my carbidopa/levodopa/entacapone prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your carbidopa/levodopa/entacapone prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient carbidopa/levodopa/entacapone savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient carbidopa/levodopa/entacapone savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for carbidopa/levodopa/entacapone | Canadian Prescription Savings* for carbidopa/levodopa/entacapone | carbidopa/levodopa/entacapone Drug Coupon* | carbidopa/levodopa/entacapone Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of carbidopa/levodopa/entacapone?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for carbidopa/levodopa/entacapone | Canadian Prescription Savings* for carbidopa/levodopa/entacapone | carbidopa/levodopa/entacapone Drug Coupon* | carbidopa/levodopa/entacapone Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the carbidopa/levodopa/entacapone savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the carbidopa/levodopa/entacapone drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for carbidopa/levodopa/entacapone, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the carbidopa/levodopa/entacapone prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, carbidopa/levodopa/entacapone is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed carbidopa/levodopa/entacapone for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the carbidopa/levodopa/entacapone prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the carbidopa/levodopa/entacapone prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for carbidopa/levodopa/entacapone
If you are having trouble paying for your carbidopa/levodopa/entacapone medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for carbidopa/levodopa/entacapone you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- carbidopa/levodopa/entacapone is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers carbidopa/levodopa/entacapone
- If carbidopa/levodopa/entacapone is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for carbidopa/levodopa/entacapone
If you are having trouble paying for your carbidopa/levodopa/entacapone medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for carbidopa/levodopa/entacapone you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers carbidopa/levodopa/entacapone
- If carbidopa/levodopa/entacapone is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for carbidopa/levodopa/entacapone
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your carbidopa/levodopa/entacapone treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for carbidopa/levodopa/entacapone you will need to meet the following criteria:
- You must be currently insured and have coverage for carbidopa/levodopa/entacapone
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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You can lower the cost of your prescription medications using our various savings programs which include drug coupons, savings card and manufacturer-sponsored patient assistance programs.
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