Used for Cancer

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Manufactured by Bristol-Myers Squibb

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

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    You can receive for FREE


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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

SPRYCEL Uses, Side Effects, Interactions, Warnings & Dosing

What is SPRYCEL?

What is SPRYCEL?

SPRYCEL is the brand name for dasatinib and is available as an oral tablet.

What dosages is SPRYCEL available in?

What dosages is SPRYCEL available in?

SPRYCEL is available as a 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, and 140 mg oral tablet.

What is SPRYCEL used for?

What is SPRYCEL used for?

SPRYCEL is a tyrosine kinase inhibitor that is used to treat:
Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)

How does SPRYCEL work?

How does SPRYCEL work?

SPRYCEL is a tyrosine kinase inhibitor (TKI). It blocks a certain protein in your body called BCR-ABL tyrosine kinase. This protein is found on cancer cells like CML and ALL and not on normal, healthy cells. It causes the cancer cells to grow and multiply. By blocking this protein, it kills cancer cells and stops their spread.

How do I take SPRYCEL?

How do I take SPRYCEL?

SPRYCEL is dosed as follows:

  • Adults with Ph+ CML: Dosing will depend on the phase of Ph+ CML you’re in. The typical dose starts at 100 mg or 140 mg by mouth once a day
  • Adults with Ph+ ALL: The typical dose is 140 mg by mouth once a day
  • Children with Ph+ CML or Ph+ ALL: Dosing will depend on the child’s weight. Dosage starts from 40 mg to 100 mg by mouth once a day

Your dose might differ if you’re taking certain medications that interact with SPRYCEL.

Is it safe for me to take SPRYCEL?

Is it safe for me to take SPRYCEL?

SPRYCEL is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

SPRYCEL Common Side Effects

SPRYCEL Common Side Effects

Common side effects of SPRYCEL:

  • Fluid buildup or swelling
  • Headache
  • Diarrhea
  • Tiredness
  • Bleeding
  • Trouble breathing
  • Nausea
  • Muscle, joint, or bone pain
  • Rash
  • Fever
  • Vomiting
SPRYCEL Serious Side Effects

SPRYCEL Serious Side Effects

Serious side effects are rare with SPRYCEL. Contact your healthcare provider immediately if you experience any of the following.

  • Infection: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
  • Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, blood in the urine, throwing up blood, bloody or black and tarry stool
  • Heart problems: chest pain, racing heart, shortness of breath, swelling of legs or feet, sudden weight gain, fatigue, dizziness, weakness on one side of body, problems with vision or speech
  • Abnormal electrolyte levels and kidney problems: dark urine, not urinating as much as usual, pain on either side of the lower back, racing heart, muscle cramps or spasms, numbness, nausea, vomiting
Effects of other drugs, drug classes and over-the-counter products on SPRYCEL

Effects of other drugs, drug classes and over-the-counter products on SPRYCEL

The following medications may interact with SPRYCEL:

  • Strong CYP3A4 Inhibitors: Dose reduction may be necessary
  • Strong CYP3A4 Inducers: Dose increase may be necessary
  • Antacids: Avoid simultaneous administration
  • H2 Antagonists and Proton Pump Inhibitors: Avoid coadministration
Who makes SPRYCEL?

Who makes SPRYCEL?

Bristol-Myers Squibb

Is SPRYCEL safe in pregnancy?

Is SPRYCEL safe in pregnancy?

SPRYCEL can harm your unborn baby.

Females who can become pregnant:

  • You should not become pregnant during treatment with SPRYCEL
  • You should use effective birth control (contraception) during treatment and for 30 days after your last dose of
  • Talk to your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with SPRYCEL

Males with female partners who can become pregnant:

  • You should use effective birth control (contraception) during treatment and for 30 days after your last dose of
  • Your female partner should call her healthcare provider if she becomes pregnant or thinks she is pregnant during
    your treatment with SPRYCEL

What to do if you missed your SPRYCEL dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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