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Dasatinib is available as a 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, and 140 mg oral tablet.

Dasatinib is a tyrosine kinase inhibitor that is used to treat:
Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)

Dasatinib is a tyrosine kinase inhibitor (TKI). It blocks a certain protein in your body called BCR-ABL tyrosine kinase. This protein is found on cancer cells like CML and ALL and not on normal, healthy cells. It causes the cancer cells to grow and multiply. By blocking this protein, it kills cancer cells and stops their spread.

Dasatinib is dosed as follows:

• Adults with Ph+ CML: Dosing will depend on the phase of Ph+ CML you’re in. The typical dose starts at 100 mg or 140 mg by mouth once a day
• Adults with Ph+ ALL: The typical dose is 140 mg by mouth once a day
• Children with Ph+ CML or Ph+ ALL: Dosing will depend on the child’s weight. Dosage starts from 40 mg to 100 mg by mouth once a day

Your dose might differ if you’re taking certain medications that interact with Dasatinib.

Dasatinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Dasatinib:

• Fluid buildup or swelling
• Headache
• Diarrhea
• Tiredness
• Bleeding
• Trouble breathing
• Nausea
• Muscle, joint, or bone pain
• Rash
• Fever
• Vomiting

Serious side effects are rare with Dasatinib. Contact your healthcare provider immediately if you experience any of the following.

• Infection: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
• Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, blood in the urine, throwing up blood, bloody or black and tarry stool
• Heart problems: chest pain, racing heart, shortness of breath, swelling of legs or feet, sudden weight gain, fatigue, dizziness, weakness on one side of body, problems with vision or speech
• Abnormal electrolyte levels and kidney problems: dark urine, not urinating as much as usual, pain on either side of the lower back, racing heart, muscle cramps or spasms, numbness, nausea, vomiting

The following medications may interact with Dasatinib:

• Strong CYP3A4 Inhibitors: Dose reduction may be necessary
• Strong CYP3A4 Inducers: Dose increase may be necessary
• Antacids: Avoid simultaneous administration
• H2 Antagonists and Proton Pump Inhibitors: Avoid coadministration

Various FDA-approved generic manufacturers

Dasatinib can harm your unborn baby.

Females who can become pregnant:

• You should not become pregnant during treatment with Dasatinib
• You should use effective birth control (contraception) during treatment and for 30 days after your last dose of
  Dasatinib
• Talk to your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Dasatinib

Males with female partners who can become pregnant:

• You should use effective birth control (contraception) during treatment and for 30 days after your last dose of
  Dasatinib
• Your female partner should call her healthcare provider if she becomes pregnant or thinks she is pregnant during
  your treatment with Dasatinib

• Sprycel