selpercatinib
Used for Cancer
Are you tired of high medication costs? Our service offers unbeatable savings on your selpercatinib prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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Lower the cost of your selpercatinib prescription
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selpercatinib key facts
What dosages is selpercatinib available in?
selpercatinib is available as a 40 mg and 80 mg oral capsule.
What is selpercatinib used for?
selpercatinib is a RET inhibitor that is used to treat:
- Advanced or metastatic NSCLC with RET gene fusion in adults
- Advanced or metastatic thyroid cancers with RET mutations in adults and children age 12 years and older
- Advanced or metastatic tumors with RET mutations in adults, when other treatments haven’t worked or aren’t available
How does selpercatinib work?
selpercatinib is a protein in the body that signals cells to grow and divide. Your body makes RET proteins using instructions given by the RET gene. In certain cancers, changes (mutations) in the RET gene lead to abnormal RET proteins. These abnormal proteins cause cancer cells to grow out of control. selpercatinib is a type of kinase inhibitor called a RET inhibitor. It blocks the RET protein, so the cancer can’t grow and spread as easily.
How do I take selpercatinib?
- The dose of selpercatinib is based on your weight
- People weighing 110 lb or more: The typical dose is 160 mg by mouth twice a day, about 12 hours apart
- People weighing less than 110 lb: The typical dose is 120 mg by mouth twice a day, about 12 hours apart
Is it safe for me to take selpercatinib?
selpercatinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
selpercatinib Common Side Effects
Common side effects of selpercatinib:
- Signs of stress to the liver or kidney on blood tests
- Abnormal electrolyte levels in the blood
- Lower blood cell counts
- Swelling
- Diarrhea
- Feeling very tired
- Dry mouth
- High blood pressure
- Stomach pain
- Constipation
- Rash
- Nausea
- Headache
selpercatinib Serious Side Effects
Serious side effects are rare with selpercatinib. Contact your healthcare provider immediately if you experience any of the following.
- Liver injury: pain in the right side of the stomach, yellowing of the eyes or skin, dark or brown urine
- Lung damage: cough, shortness of breath, fever
High blood pressure: headache, dizziness, confusion, chest pain - Abnormal heart rhythm: chest pain, shortness of breath, dizziness, fluttering or pounding heart beat
- Severe bleeding: sudden or painful headache, changes in vision, severe stomach pain, coughing or spitting up blood
- Tumor lysis syndrome: muscle cramps, dark or brown urine, fluttering or pounding heart beat
- Allergic reaction: fever, rash, muscle, bone, or joint pain
Effects of other drugs, drug classes and over-the-counter products on selpercatinib
The following medications may interact with selpercatinib:
- Acid-Reducing Agents: Avoid coadministration. If coadministrationncannot be avoided, take selpercatinib with food (with PPI) or modify its administration time (with H2 receptor antagonist or locally-acting antacid).
- • Strong and Moderate CYP3A Inhibitors: Avoid coadministration. If coadministration cannot be avoided, reduce the selpercatinib dose
- • Strong and Moderate CYP3A Inducers: Avoid coadministration. (CYP2C8 and CYP3A Substrates: Avoid coadministration. If coadministration cannot be avoided, modify the substrate dosage as recommended in its product labeling
- • Certain P-gp Substrates: Avoid coadministration. If coadministration cannot be avoided, modify the substrate dosage as recommended in its product labelin.
Who makes selpercatinib?
Various FDA-approved generic manufacturers
Is selpercatinib safe in pregnancy?
Based on data from animal reproduction studies and its mechanism of action, selpercatinib can cause fetal harm when
administered to a pregnant woman. If you can become pregnant, you should use effective contraception during treatment with selpercatinib and for 1 week after the last dose. Males with female partners of reproductive potential to use effective contraception during treatment with selpercatinib and for 1 week after the last dose.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my selpercatinib prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your selpercatinib prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient selpercatinib savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient selpercatinib savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for selpercatinib | Canadian Prescription Savings* for selpercatinib | selpercatinib Drug Coupon* | selpercatinib Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of selpercatinib?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for selpercatinib | Canadian Prescription Savings* for selpercatinib | selpercatinib Drug Coupon* | selpercatinib Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the selpercatinib savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the selpercatinib drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for selpercatinib, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the selpercatinib prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, selpercatinib is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed selpercatinib for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the selpercatinib prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the selpercatinib prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for selpercatinib
If you are having trouble paying for your selpercatinib medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for selpercatinib you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- selpercatinib is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers selpercatinib
- If selpercatinib is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for selpercatinib
If you are having trouble paying for your selpercatinib medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for selpercatinib you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers selpercatinib
- If selpercatinib is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for selpercatinib
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your selpercatinib treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for selpercatinib you will need to meet the following criteria:
- You must be currently insured and have coverage for selpercatinib
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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You can lower the cost of your prescription medications using our various savings programs which include drug coupons, savings card and manufacturer-sponsored patient assistance programs.
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