Used for Cancer

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

RETEVMO Uses, Side Effects, Interactions, Warnings & Dosing

What is RETEVMO?

What is RETEVMO?

RETEVMO is the brand name for selpercatinib and is available as an oral capsule.

What dosages is RETEVMO available in?

What dosages is RETEVMO available in?

RETEVMO is available as a 40 mg and 80 mg oral capsule.

What is RETEVMO used for?

What is RETEVMO used for?

RETEVMO is a RET inhibitor that is used to treat:

  • Advanced or metastatic NSCLC with RET gene fusion in adults
  • Advanced or metastatic thyroid cancers with RET mutations in adults and children age 12 years and older
  • Advanced or metastatic tumors with RET mutations in adults, when other treatments haven’t worked or aren’t available
How does RETEVMO work?

How does RETEVMO work?

RETEVMO is a protein in the body that signals cells to grow and divide. Your body makes RET proteins using instructions given by the RET gene. In certain cancers, changes (mutations) in the RET gene lead to abnormal RET proteins. These abnormal proteins cause cancer cells to grow out of control. RETEVMO is a type of kinase inhibitor called a RET inhibitor. It blocks the RET protein, so the cancer can’t grow and spread as easily.

How do I take RETEVMO?

How do I take RETEVMO?

  • The dose of RETEVMO is based on your weight
  • People weighing 110 lb or more: The typical dose is 160 mg by mouth twice a day, about 12 hours apart
  • People weighing less than 110 lb: The typical dose is 120 mg by mouth twice a day, about 12 hours apart
Is it safe for me to take RETEVMO?

Is it safe for me to take RETEVMO?

RETEVMO is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

RETEVMO Common Side Effects

RETEVMO Common Side Effects

Common side effects of RETEVMO:

  • Signs of stress to the liver or kidney on blood tests
  • Abnormal electrolyte levels in the blood
  • Lower blood cell counts
  • Swelling
  • Diarrhea
  • Feeling very tired
  • Dry mouth
  • High blood pressure
  • Stomach pain
  • Constipation
  • Rash
  • Nausea
  • Headache
RETEVMO Serious Side Effects

RETEVMO Serious Side Effects

Serious side effects are rare with RETEVMO. Contact your healthcare provider immediately if you experience any of the following.

  • Liver injury: pain in the right side of the stomach, yellowing of the eyes or skin, dark or brown urine
  • Lung damage: cough, shortness of breath, fever
    High blood pressure: headache, dizziness, confusion, chest pain
  • Abnormal heart rhythm: chest pain, shortness of breath, dizziness, fluttering or pounding heart beat
  • Severe bleeding: sudden or painful headache, changes in vision, severe stomach pain, coughing or spitting up blood
  • Tumor lysis syndrome: muscle cramps, dark or brown urine, fluttering or pounding heart beat
  • Allergic reaction: fever, rash, muscle, bone, or joint pain
Effects of other drugs, drug classes and over-the-counter products on RETEVMO

Effects of other drugs, drug classes and over-the-counter products on RETEVMO

The following medications may interact with RETEVMO:

  • Acid-Reducing Agents: Avoid coadministration. If coadministrationncannot be avoided, take RETEVMO with food (with PPI) or modify its administration time (with H2 receptor antagonist or locally-acting antacid).
  • • Strong and Moderate CYP3A Inhibitors: Avoid coadministration. If coadministration cannot be avoided, reduce the RETEVMO dose
  • • Strong and Moderate CYP3A Inducers: Avoid coadministration. (CYP2C8 and CYP3A Substrates: Avoid coadministration. If coadministration cannot be avoided, modify the substrate dosage as recommended in its product labeling
  • • Certain P-gp Substrates: Avoid coadministration. If coadministration cannot be avoided, modify the substrate dosage as recommended in its product labelin.
Who makes RETEVMO?

Who makes RETEVMO?

Eli Lilly & Company

Is RETEVMO safe in pregnancy?

Is RETEVMO safe in pregnancy?

Based on data from animal reproduction studies and its mechanism of action, RETEVMO can cause fetal harm when
administered to a pregnant woman. If you can become pregnant, you should use effective contraception during treatment with RETEVMO and for 1 week after the last dose. Males with female partners of reproductive potential to use effective contraception during treatment with RETEVMO and for 1 week after the last dose.


What to do if you missed your RETEVMO dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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