RYDAPT
Used for Cancer
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Manufactured by Novartis Pharmaceuticals
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RYDAPT Uses, Side Effects, Interactions, Warnings & Dosing
What is RYDAPT?
RYDAPT is the brand name for midostaurin and is available as an oral capsule.
What dosages is RYDAPT available in?
RYDAPT is available as a 25 mg oral capsule.
What is RYDAPT used for?
RYDAPT is a tyrosine kinase inhibitor and is used for the following:
- Acute myeloid leukemia (AML) with a specific mutation (FLT3-positive)
- Mast cell leukemia and systemic mastocytosis
How does RYDAPT work?
RYDAPT is a type of targeted therapy called a tyrosine kinase inhibitor. Kinases are enzymes (proteins) that send signals to cells, including cancer cells, that tells them to grow. RYDAPT works by blocking several kinases in blood cancer (leukemia) cells, which then prevents these cells from growing. RYDAPT works specifically on leukemia cells that have the FLT3 mutation. For systemic mastocytosis and mast cell leukemia, RYDAPT is thought to work by slowing or stopping the growth of abnormal mast cells. It might also block the release of histamines that cause symptoms of systemic mastocytosis.
How do I take RYDAPT?
RYDAPT is dosed as follows:
- AML: The typical dosing is 50 mg by mouth twice daily on Day 8 through 21 of each treatment cycle
- Mast cell leukemia and systemic mastocytosis: The typical dosing is 100 mg by mouth twice daily
- Your provider might adjust your dose if you experience certain side effects or if you’re taking medications that might interact with RYDAPT
Is it safe for me to take RYDAPT?
RYDAPT is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
RYDAPT Common Side Effects
Common side effects of RYDAPT:
- Nausea
- Fever from low white blood cell counts
- High blood sugar levels
- Lower blood calcium levels
- Vomiting
- Redness, pain, or ulcers on the inside of the mouth
- Abnormal blood cell counts
- Diarrhea
- Headache
- Swelling in the hands and feet
- Abnormal liver labs
- Higher pancreatic enzyme levels
- Higher uric acid levels
- Red/brown/purple spots on skin
RYDAPT Serious Side Effects
Serious side effects are rare with RYDAPT. Contact your healthcare provider immediately if you experience any of the following.
- Lung problems: cough, trouble breathing, chest pain
Effects of other drugs, drug classes and over-the-counter products on RYDAPT
The following medications may interact with RYDAPT:
- Strong CYP3A4 Inhibitors: Strong CYP3A4 inhibitors may increase exposure to midostaurin and its active metabolites. Consider alternative therapies that do not strongly inhibit CYP3A4 or monitor for increased risk of adverse reactions
- Strong CYP3A4 Inducers: Avoid concomitant use as strong CYP3A4 inducers decrease exposure to midostaurin and its active metabolites. (7.1)
- CYP2B6, BCRP, OATP1B1 Substrates: Dose adjustments for coadministered CYP2B6, BCRP, and OATP1B1 substrates may be necessary with RYDAPT
Who makes RYDAPT?
Novartis Pharmaceuticals
Is RYDAPT safe in pregnancy?
RYDAPT may cause harm to your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with RYDAPT or think you may be pregnant.
Pregnancy Registry: There is a pregnancy registry that monitors the health of females and their babies exposed
to RYDAPT during pregnancy. Females who have taken RYDAPT during pregnancy or have been exposed to
RYDAPT during pregnancy through a male partner taking RYDAPT should contact Novartis Pharmaceuticals
Corporation at 1-888-669-6682, or at Report Novartis
If you are able to become pregnant, your healthcare provider may perform a pregnancy test within 7 days before you start RYDAPT. Females who are able to become pregnant should use effective birth control (contraception) during treatmentwith RYDAPT and for 4 months after the last dose of RYDAPT. Males who have female partners that are able to become pregnant should use effective birth control during
treatment with RYDAPT and for 4 months after the last dose of RYDAPT.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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