midostaurin
Used for Cancer
NowPatient helps you obtain your midostaurin prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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midostaurin key facts
What dosages is midostaurin available in?
midostaurin is available as a 25 mg oral capsule.
What is midostaurin used for?
midostaurin is a tyrosine kinase inhibitor and is used for the following:
- Acute myeloid leukemia (AML) with a specific mutation (FLT3-positive)
- Mast cell leukemia and systemic mastocytosis
How does midostaurin work?
midostaurin is a type of targeted therapy called a tyrosine kinase inhibitor. Kinases are enzymes (proteins) that send signals to cells, including cancer cells, that tells them to grow. midostaurin works by blocking several kinases in blood cancer (leukemia) cells, which then prevents these cells from growing. midostaurin works specifically on leukemia cells that have the FLT3 mutation. For systemic mastocytosis and mast cell leukemia, midostaurin is thought to work by slowing or stopping the growth of abnormal mast cells. It might also block the release of histamines that cause symptoms of systemic mastocytosis.
How do I take midostaurin?
midostaurin is dosed as follows:
- AML: The typical dosing is 50 mg by mouth twice daily on Day 8 through 21 of each treatment cycle
- Mast cell leukemia and systemic mastocytosis: The typical dosing is 100 mg by mouth twice daily
- Your provider might adjust your dose if you experience certain side effects or if you’re taking medications that might interact with midostaurin
Is it safe for me to take midostaurin?
midostaurin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
midostaurin Common Side Effects
Common side effects of midostaurin:
- Nausea
- Fever from low white blood cell counts
- High blood sugar levels
- Lower blood calcium levels
- Vomiting
- Redness, pain, or ulcers on the inside of the mouth
- Abnormal blood cell counts
- Diarrhea
- Headache
- Swelling in the hands and feet
- Abnormal liver labs
- Higher pancreatic enzyme levels
- Higher uric acid levels
- Red/brown/purple spots on skin
midostaurin Serious Side Effects
Serious side effects are rare with midostaurin. Contact your healthcare provider immediately if you experience any of the following.
- Lung problems: cough, trouble breathing, chest pain
Effects of other drugs, drug classes and over-the-counter products on midostaurin
The following medications may interact with midostaurin:
- Strong CYP3A4 Inhibitors: Strong CYP3A4 inhibitors may increase exposure to midostaurin and its active metabolites. Consider alternative therapies that do not strongly inhibit CYP3A4 or monitor for increased risk of adverse reactions
- Strong CYP3A4 Inducers: Avoid concomitant use as strong CYP3A4 inducers decrease exposure to midostaurin and its active metabolites. (7.1)
- CYP2B6, BCRP, OATP1B1 Substrates: Dose adjustments for coadministered CYP2B6, BCRP, and OATP1B1 substrates may be necessary with midostaurin
Who makes midostaurin?
Various FDA-approved generic manufacturers
Is midostaurin safe in pregnancy?
midostaurin may cause harm to your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with midostaurin or think you may be pregnant.
Pregnancy Registry: There is a pregnancy registry that monitors the health of females and their babies exposed
to midostaurin during pregnancy. Females who have taken midostaurin during pregnancy or have been exposed to
midostaurin during pregnancy through a male partner taking midostaurin should contact Novartis Pharmaceuticals
Corporation at 1-888-669-6682, or at Report Novartis
If you are able to become pregnant, your healthcare provider may perform a pregnancy test within 7 days before you start midostaurin. Females who are able to become pregnant should use effective birth control (contraception) during treatmentwith midostaurin and for 4 months after the last dose of midostaurin. Males who have female partners that are able to become pregnant should use effective birth control during
treatment with midostaurin and for 4 months after the last dose of midostaurin.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my midostaurin prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your midostaurin prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient midostaurin savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient midostaurin savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for midostaurin | Canadian Prescription Savings* for midostaurin | midostaurin Drug Coupon* | midostaurin Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of midostaurin?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for midostaurin | Canadian Prescription Savings* for midostaurin | midostaurin Drug Coupon* | midostaurin Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the midostaurin savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the midostaurin drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for midostaurin, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the midostaurin prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, midostaurin is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed midostaurin for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the midostaurin prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the midostaurin prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for midostaurin
If you are having trouble paying for your midostaurin medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for midostaurin you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- midostaurin is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers midostaurin
- If midostaurin is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for midostaurin
If you are having trouble paying for your midostaurin medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for midostaurin you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers midostaurin
- If midostaurin is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for midostaurin
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your midostaurin treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for midostaurin you will need to meet the following criteria:
- You must be currently insured and have coverage for midostaurin
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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