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Rybelsus is the brand name for semaglutide and is available as an oral tablet.

Rybelsus is available as 3 mg, 7 mg, and 14 mg oral tablet.

• Rybelsus is a glucagon-like peptide-1 (GLP-1) agonist and is used to treat type 2 diabetes

Rybelsus is a glucagon-like peptide-1 (GLP-1) agonist, meaning it acts like the natural GLP-1 hormone in the body. This hormone works to lower your blood sugar by causing your pancreas to release more insulin, stopping your liver from releasing more sugar, and slowing down your digestion.

• Rybelsus is typically started at 3 mg by mouth once per day for 30 days. After 30 days, your dose will be raised to 7 mg once per day. If needed, your provider might raise your dose again to 14 mg once per day

Rybelsus is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine.
• Neoplasia syndrome type 2
• Prior serious hypersensitivity reaction to semaglutide or any of the excipients in Rybelsus

Common side effects of Rybelsus:

• Nausea
• Stomach pain
• Diarrhea
• Lower appetite
• Vomiting
• Constipation

Serious side effects are rare with Rybelsus. Contact your healthcare provider immediately if you experience any of the following.

• Thyroid cancer: mass in the neck, trouble breathing or swallowing, hoarseness
• Inflammation of the pancreas (pancreatitis): stomach or back pain that won’t go away, vomiting
• Low blood sugar: shaking, sweating, dizziness, confusion, blurred vision
• Kidney damage: tiredness, dry and itchy skin, urinating more often, bloody or foamy urine, swelling in your feet or ankles, muscle cramping
• Gallbladder problems: pain in the upper stomach, fever, yellowing of the whites of the eyes, clay-colored stool
• Serious allergic reactions: trouble breathing, hives, swelling of your face, lips, tongue, or throat

The following medications may interact with Rybelsus:

• Oral Medications: Rybelsus delays gastric emptying. Instruct patients to closely follow
• Rybelsus administration instructions

Novo Nordisk Inc.

Discontinue Rybelsus in women at least 2 months before a planned pregnancy due to the long washout period for semaglutide.

• Semaglutide