ROCALTROL

Calcitriol is a medication used to address low calcium levels associated with kidney disease and parathyroid gland disorders. It functions by increasing calcium (vitamin D) levels in the body and is marketed under the brand name Rocaltrol.

Instructions for Rocaltrol Usage: Administer this medication orally as per your doctor’s guidance, usually once daily, with or without food.

Calcitriol acts upon gastrointestinal cells, stimulating the production of calcium transport proteins known as calbindin-D proteins. This process enhances the absorption of calcium from the intestines into the body, representing the sole mechanism for increasing calcium reserves.

In cases of kidney failure, calcitriol levels progressively decrease, impacting calcium and phosphorus homeostasis and contributing to the development of renal secondary hyperparathyroidism (SHPT).

It is crucial not to discontinue Calcitriol-AFT or modify the dosage without consulting your physician. Sudden cessation can lead to a rapid drop in blood calcium levels. Your doctor will provide guidance on gradually reducing the dosage of Calcitriol-AFT before discontinuation.

Symptoms of calcitriol overdose (hypercalcemia) include anorexia, nausea, vomiting, polyuria, polydipsia, and weakness. Treatment for calcitriol overdose involves general supportive measures and immediate discontinuation of calcitriol, along with adopting a low calcium diet.

In some instances, CALCITRIOL+CALCIUM CARBONATE+ZINC can lead to side effects such as constipation, stomach upset, nausea, vomiting, loss of appetite, mood changes, weakness, tiredness, fast or pounding heartbeat, bone/muscle pain, and headache.

Calcitriol (Rocaltrol) represents a form of vitamin D utilized to elevate blood calcium levels and is commonly prescribed for individuals with kidney and parathyroid hormone-related issues.

Calcitriol is a variant of vitamin D3, which aids in calcium absorption from the stomach. It is used in the treatment of hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in individuals with chronic kidney failure who are not undergoing dialysis.

Calcitriol, the most active form of vitamin D [100 times more potent than 25(OH)D3], has a brief half-life of a few hours. Initially believed to be exclusively produced in the kidneys, it is now acknowledged to be present in numerous extrarenal tissues.

Vitamin D3 is more effective in maintaining elevated vitamin D levels in the bloodstream over an extended duration compared to vitamin D2. Vitamin D2 is sourced from plants, while vitamin D3 is derived from animals, making vitamin D2 a suitable option for those who prefer plant-based products.

Calcitriol closely resembles other forms of vitamin D. Refrain from using medications containing different forms of vitamin D while using calcitriol, as it may interfere with specific laboratory tests, potentially yielding false results.

List of medications: Aspir 81 (aspirin), Aspirin Low Strength (aspirin), Calcium 600 D (calcium/vitamin D), Colace (docusate), Coreg (carvedilol), Crestor (rosuvastatin), Cymbalta (duloxetine), Eliquis (apixaban).

By the early 1970s, it had become evident that calcitriol was the active form of vitamin D, exhibiting over 1,000 times greater potency in binding to the vitamin D receptor compared to Vitamin D2 and D3.

Calcitriol is the active form of vitamin D, typically synthesized in the kidneys. Also known as 1,25-dihydroxycholecalciferol, it functions as a hormone by binding to and activating the vitamin D receptor in the cell’s nucleus, subsequently increasing the expression of numerous genes.

Calcitriol – AFT 0.25 g: Each capsule contains 0.25 g of synthetic calcitriol, a biologically active form of vitamin D3. Calcitriol – AFT 0.5 g: Each capsule contains 0.5 g of synthetic calcitriol, a biologically active form of vitamin D3.

1,25-dihydroxyvitamin D3 [1,25(OH)2D3 or calcitriol], the hormonally active vitamin D metabolite, exhibits anti-cancer properties in models of breast and prostate cancer.

Calcitriol is a synthetic version of Vitamin D3 utilized in the treatment of calcium deficiency associated with hypoparathyroidism (impaired parathyroid gland function) and metabolic bone disease in individuals with chronic kidney failure. It is available under various brand names, including Calcijex and Rocaltrol.

By the early 1970s, it was established that calcitriol is the active form of vitamin D, possessing more than 1,000 times the binding affinity to the vitamin D receptor compared to Vitamin D2 and D3.

Calcitriol (Rocaltrol) is available in the form of capsules and a liquid for oral administration and is offered both as a brand-name and generic medication.

C 1,25-Dihydroxyvitamin D3 (Calcitriol) is the active form of vitamin D, crucial for calcium absorption and bone mineralization.

Calcidol is the primary circulating metabolite of cholecalciferol, while calcitriol is the hormone responsible for enhancing the active transport of calcium from the gut and inhibiting parathyroid hormone secretion.

Moreover, curcumin is an active herbal compound that offers a cost-effective and readily available alternative to calcitriol for stimulating bone health. It can also be integrated into materials designed to promote ossification, such as guided bone regeneration (GBR).

Calcitriol plays a vital role in treating vitamin D deficiency in individuals with renal failure, particularly when there is an impaired conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D. Close monitoring of serum calcium levels and renal function is essential in such cases.

Calcitriol closely resembles other forms of vitamin D. It is essential to avoid using medications containing different vitamin D forms while on calcitriol treatment, as this medication may potentially interfere with specific laboratory tests, leading to inaccurate results.

Calcitonin and calcitriol are both hormones that impact calcium levels, albeit with distinct functions. Calcitriol promotes the elevation of blood calcium levels, while calcitonin works to reduce blood calcium levels.

Calcitriol represents a form of vitamin D and is exclusively available through a doctor’s prescription. It is offered in various dosage forms, including ointment.

Vitamin D3 undergoes conversion into the active form of vitamin D, known as calcitriol, either through dietary intake or sunlight exposure. Both vitamin D2 and D3 effectively raise blood vitamin D levels, but research indicates that D3 is more readily absorbed and better at maintaining optimal vitamin D levels compared to D2.

Calcitriol, a synthetic form of Vitamin D, regulates calcium absorption and promotes bone strength. Methylcobalamin, an active form of Vitamin B12, supports proper cell growth, protein synthesis, and the production of blood cells, including red and white blood cells.

While uncommon, some side effects can be serious. If you experience fatigue, difficulty concentrating, loss of appetite, nausea, vomiting, constipation, increased thirst, increased urination, or weight loss, contact your doctor immediately.

Avoid using medications containing alternative forms of vitamin D while on calcitriol treatment, as this medication may potentially interfere with specific laboratory tests, potentially leading to inaccurate results. Ensure that both lab personnel and your healthcare providers are aware of your use of this drug.

Calcitriol is used in the treatment of kidney disease patients who are unable to produce an adequately active form of Vitamin D. It is also utilized to prevent and manage complications related to calcium, phosphorus, and parathyroid function that may arise from long-term kidney dialysis or hypoparathyroidism.

A study demonstrated that administering calcitriol at night (11:00 PM) significantly reduced the occurrence of hypercalcemia. While over 80% of patients developed hypercalcemia when calcitriol was administered in the morning, this figure dropped to only 50% when administered at night (P less than 0.013).

Lower concentrations of calcitriol are independently associated with a decline in kidney function among older adults living in the community.

One of the more common side effects of Calcitriol is weight loss. As an activated form of vitamin D, this drug is a crucial metabolite in maintaining calcium and phosphorus levels.

Calcitriol closely resembles other forms of vitamin D. To avoid potential interference with specific laboratory tests, such as cholesterol tests, it is important not to use medications containing different forms of vitamin D while taking calcitriol.

Reduced levels of the calcitriol precursor, 25-hydroxyvitamin D, are linked to conditions such as myocardial infarction, congestive heart failure, and calcific aortic stenosis. In cases of chronic kidney disease, deficient calcitriol concentrations are likely to contribute to extensive vascular calcification.