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Manufactured by various FDA-approved generic manufacturers.

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

calcitriol Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is calcitriol available in?

What dosages is calcitriol available in?

calcitriol is available as a 0.25 mcg and 0.5 mcg oral capsule and 1 mcg/ml oral solution.

What is calcitriol used for?

What is calcitriol used for?

calcitriol is a form of vitamin D that is used to treat:
Low calcium in people on dialysis Secondary hyperparathyroidism in people not yet on dialysis
Low calcium in people with hypoparathyroidism or pseudohypoparathyroidism

How does calcitriol work?

How does calcitriol work?

calcitriol is the active form of vitamin D. It raises your vitamin D levels, which helps your body absorb more calcium. This raises your blood calcium levels.

How do I take calcitriol?

How do I take calcitriol?

calcitriol is dosed as follows:

  • Adults: The typical starting dose is 0.25 mcg by mouth daily. Your provider will check your blood calcium levels throughout therapy. They might raise your dose if your levels remain low
  • Children: Your child’s dose will depend on their age, weight, and the reason they’re taking calcitriol (calcitriol).
Is it safe for me to take calcitriol?

Is it safe for me to take calcitriol?

calcitriol is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have hypercalcemia or
evidence of vitamin D toxicity.

calcitriol Common Side Effects

calcitriol Common Side Effects

Common side effects of calcitriol:

  • Headache
  • Weakness
  • Feeling tired or sleepy
  • Upset stomach or stomach pain
  • Nausea
  • Vomiting
  • Constipation
  • Loss of appetite
  • Muscle pain
  • Bone pain
  • Dry mouth
  • Metallic taste
calcitriol Serious Side Effects

calcitriol Serious Side Effects

Serious side effects are rare with calcitriol. Contact your healthcare provider immediately if you experience any of the following.

  • Late-stage calcium toxicity: changes in urine, loss of appetite, light sensitivity, chest pain, racing heart
  • Allergic reaction: itching, rash, hives, swelling of lips
Effects of other drugs, drug classes and over-the-counter products on calcitriol

Effects of other drugs, drug classes and over-the-counter products on calcitriol

The following medications may interact with calcitriol:

  • Cholestyramine has been reported to reduce intestinal absorption of fatsoluble vitamins; as such it may impair intestinal absorption of calcitriol/
  • The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of calcitriol, but may reduce endogenous plasma levels of 25(OH)D3 by inhibiting 25-hydroxylase in liver. Since endogenous synthesis of calcitriol will be inhibited, higher doses of calcitriol may benecessary if these drugs are administered simultaneously
  • Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine
  • Some reports have shown that the concomitant administration of thiazides with calcitriol causes
  • hypercalcemia. Therefore, precaution should be taken when coadministration is necessary
  • Ketoconazole may inhibit both synthetic and catabolic enzymes of calcitriol. Reductions in serum endogenous calcitriol concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men. However, in vivo drug
  • interaction studies of ketoconazole with calcitriol have not been investigated
Who makes calcitriol?

Who makes calcitriol?

Various FDA-approved generic manufacturers

Is calcitriol safe in pregnancy?

Is calcitriol safe in pregnancy?

calcitriol should be used during
pregnancy only if the potential benefit justifies the potential risk to the fetus.


What to do if you missed your calcitriol dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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