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Riabni is the brand name for rituximab-arrx IV infusion.

Riabni is available as a 100 mg/10 mL (10 mg/mL) and 500 mg/50 mL (10mg/mL) solution in single-dose vials.

Riabni is an anti-CD20 monoclonal antibody and is used for the following:

Blood cancers:

• Certain types of CD20-positive non-Hodgkin’s lymphoma (NHL) in adults and children ages 6 months and older
• CD20-positive chronic lymphocytic leukemia (CLL) in adults

Autoimmune conditions:

• Moderate to severe rheumatoid arthritis (RA) in adults
  Granulomatosis with polyangitis (GPA) and microscopic polyangitis (MPA) in adults and children ages 2 years and older
  Moderate to severe pemphigus vulgaris in adults

Riabni is a monoclonal antibody. It targets specific immune cells called B cells that can be involved in a range of different health conditions. For example, B cells sometimes turn into cancer cells. Other times, they become overly active and cause autoimmune conditions. Riabni works by attaching a specific protein on the B cells called CD20. When it does so, it signals to the body to attack and kill that cell. As a result, these abnormal or overly active B cells can’t grow, spread, or work as well.

Riabni is dosed as follows:

• Your provider will determine your dose of Riabni based on your body surface area (BSA) in m². This medication is typically given by a healthcare provider in a hospital or infusion clinic setting. Your provider might also give you other anticancer medications along with Riabni

Riabni is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Riabni:

• Fever
• Lower white blood cell counts
• Chills
• Infection
• Weakness
• Nausea
• Headache
• Night sweats
• Rash

Serious side effects are rare with Riabni. Contact your healthcare provider immediately if you experience any of the following.

• Infusion-related reaction: swelling, trouble breathing, chest pain, low blood pressure, red skin
• Serious skin reaction: painful blisters, skin wounds, peeling skin, fever, sore throat, body aches
• Tears in the gut: sudden and severe stomach pain, fever, chills, and nausea or vomiting that won’t go away
• Infection: fever, chills, cough, muscle aches, very fast heartbeat, severe tiredness
• Tumor lysis syndrome: seizures, hallucinations, nausea, tiredness, no appetite, dark-colored urine, muscle cramps, numbness
• Serious heart problems: tiredness, weakness, dizziness, feeling faint, trouble breathing, pressure on the chest, pounding heart, irregular heart beat, sweating, feeling anxious, nausea

The following medications may interact with Riabni:

• Renal toxicity when used in combination with cisplatin

Amgen Inc.

Talk to your healthcare provider about the risks to your unborn baby if you receive Riabni during pregnancy.

Females who are able to become pregnant:

• Your healthcare provider should do a pregnancy test to see if you are pregnant before starting Riabni
• You should use effective birth control (contraception) during treatment with Riabni and for 12 months
  after your last dose of Riabni. Talk to your healthcare provider about effective birth control
• Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with Riabni

• Rituximab-ARRX