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Manufactured by various FDA-approved generic manufacturers.

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ponesimod Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is ponesimod available in?

What dosages is ponesimod available in?

ponesimod is available as a 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, and 20 mg oral tablet.

What is ponesimod used for?

What is ponesimod used for?

  • ponesimod is a sphingosine 1-phosphate receptor modulator that is used for the treatment of mutiple sclerosis (MS) relapses, including clinically isolated syndrome, relapsing-remiting disease, and active secondary progressive disease.
How does ponesimod work?

How does ponesimod work?

ponesimod is a sphingosine 1-phosphate receptor modulator. It’s not known exactly how ponesimod works for multiple sclerosis, but it might be due to how this medication lowers the number of lymphocytes (white blood cells) from entering your nervous system and preventing it from causing swelling and damage to your body.

How do I take ponesimod?

How do I take ponesimod?

  • If you’re starting ponesimod for the first time, your provider will typically prescribe the ponesimod starter pack. You’ll start with 2 mg by mouth once daily and follow the dose titration schedule for 2 weeks to reach 10 mg daily.
  • Maintenance dose:
  • After completing the starter pack, the typical maintenance dose for ponesimod is 20 mg by mouth once daily.
Is it safe for me to take ponesimod?

Is it safe for me to take ponesimod?

ponesimod is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of these apply:
In the last 6 months, experienced myocardial infarction, unstable angina,
stroke, transient ischemic attack (TIA), decompensated heart failure requiring hospitalization, or Class III/IV heart failure.
Presence of Mobitz type II second-degree, third-degree AV block, sick sinus syndrome, or sino-atrial block, unless the patient has a functioning

ponesimod Common Side Effects

ponesimod Common Side Effects

  • Common side effects of ponesimod:
  • Upper respiratory infection
  • Abnormal liver tests
  • High blood pressure
  • Urinary tract infection
  • Difficulty breathing
  • Dizziness
  • Cough
  • Arm and leg pain
  • Sleepiness
  • Fever
  • Rise in C-reactive protein levels (measures inflammation)
  • High cholesterol
  • Off balance or lightheadedness
ponesimod Serious Side Effects

ponesimod Serious Side Effects

Serious side effects are rare with ponesimod. Contact your healthcare provider immediately if you experience any of the following.

Infections: fever, tiredness, body aches, chills, nausea, vomiting, headache with fever, neck stiffness, sensitivity to light, or confusion
Slow heart rate: dizziness, lightheadedness, shortness of breath, confusion, chest pain, tiredness, or feeling like your heart is beating slowly or skipping a beat
Breathing problems: shortness of breath
Liver problems: unexplained nausea, vomiting, stomach pain, tiredness, anorexia (eating disorder), yellowing of skin or eyes, or dark urine
Vision changes: blurry vision, blind spot in center of vision, sensitivity to light, unusually colored vision

Effects of other drugs, drug classes and over-the-counter products on ponesimod

Effects of other drugs, drug classes and over-the-counter products on ponesimod

  • The following medications may interact with ponesimod:
  • Vaccines: Avoid live attenuated vaccines during and for up to 1-2 weeks
  • after treatment with ponesimod.
  • • Strong CYP3A4 and UGT1A1 Inducers: Coadministration with
  • ponesimod is not recommended.
Who makes ponesimod?

Who makes ponesimod?

Various FDA-approved generic manufacturers

Is ponesimod safe in pregnancy?

Is ponesimod safe in pregnancy?

Based on animal studies, ponesimod may cause fetal harm. Because it takes approximately 1 week to eliminate ponesimod from the body, women of childbearing potential should use effective contraception to avoid pregnancy during and for 1 week after stopping ponesimod treatment.


What to do if you missed your ponesimod dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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