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Ponvory is the brand name for ponesimod and is available as an oral tablet.

Ponvory is available as a 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, and 20 mg oral tablet.

• Ponvory is a sphingosine 1-phosphate receptor modulator that is used for the treatment of mutiple sclerosis (MS) relapses, including clinically isolated syndrome, relapsing-remiting disease, and active secondary progressive disease.

Ponvory is a sphingosine 1-phosphate receptor modulator. It’s not known exactly how Ponvory works for multiple sclerosis, but it might be due to how this medication lowers the number of lymphocytes (white blood cells) from entering your nervous system and preventing it from causing swelling and damage to your body.

• If you’re starting Ponvory for the first time, your provider will typically prescribe the Ponvory starter pack. You’ll start with 2 mg by mouth once daily and follow the dose titration schedule for 2 weeks to reach 10 mg daily.
• Maintenance dose:
• After completing the starter pack, the typical maintenance dose for Ponvory is 20 mg by mouth once daily.

Ponvory is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of these apply:
In the last 6 months, experienced myocardial infarction, unstable angina,
stroke, transient ischemic attack (TIA), decompensated heart failure requiring hospitalization, or Class III/IV heart failure.
Presence of Mobitz type II second-degree, third-degree AV block, sick sinus syndrome, or sino-atrial block, unless the patient has a functioning
pacemaker.

• Common side effects of Ponvory:
• Upper respiratory infection
• Abnormal liver tests
• High blood pressure
• Urinary tract infection
• Difficulty breathing
• Dizziness
• Cough
• Arm and leg pain
• Sleepiness
• Fever
• Rise in C-reactive protein levels (measures inflammation)
• High cholesterol
• Off balance or lightheadedness

Serious side effects are rare with Ponvory. Contact your healthcare provider immediately if you experience any of the following.

Infections: fever, tiredness, body aches, chills, nausea, vomiting, headache with fever, neck stiffness, sensitivity to light, or confusion
Slow heart rate: dizziness, lightheadedness, shortness of breath, confusion, chest pain, tiredness, or feeling like your heart is beating slowly or skipping a beat
Breathing problems: shortness of breath
Liver problems: unexplained nausea, vomiting, stomach pain, tiredness, anorexia (eating disorder), yellowing of skin or eyes, or dark urine
Vision changes: blurry vision, blind spot in center of vision, sensitivity to light, unusually colored vision

• The following medications may interact with Ponvory:
• Vaccines: Avoid live attenuated vaccines during and for up to 1-2 weeks
• after treatment with Ponvory.
• • Strong CYP3A4 and UGT1A1 Inducers: Coadministration with
• Ponvory is not recommended.

Janssen Pharmaceuticals

Based on animal studies, Ponvory may cause fetal harm. Because it takes approximately 1 week to eliminate Ponvory from the body, women of childbearing potential should use effective contraception to avoid pregnancy during and for 1 week after stopping Ponvory treatment.

• Ponesimod