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Periactin is the brand name for cyproheptadine and is available as an oral tablet and syrup.

Periactin is available as a 4 mg oral tablet and a 2 mg/5 ml oral syrup.

Periactin is an antihistamine and is used to treat the following:

• Year-round and seasonal allergies
• Sneezing, stuffy, or runny nose not caused by allergies or infections (vasomotor rhinitis)
• Eye allergies
• Mild skin allergies
• Allergic reactions to blood or the liquid part of blood (plasma)
• Skin reactions due to exposure to cold temperatures (cold urticaria)
• Allergic reactions when skin is scratched (dermatographia)
• Add-on therapy for severe allergic reactions (anaphylaxis)

Periactin is first-generation antihistamine. It works by blocking histamine, which is a chemical in your body that’s released during an allergic reaction. Blocking histamine helps ease allergy symptoms, such as sneezing, stuffy or runny nose, and itchy eyes or skin. Periactin also has anticholinergic effects, which can cause symptoms such as constipation, dry eyes, and difficulty urinating.

Periactin is typically taken as 4 mg by mouth three times a day. The typical recommended dose ranges from 4 mg to 20 mg daily.

Periactin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in newborn or premature infants or in the following:

• Angle-closure glaucoma
• Stenosing peptic ulcer
• Symptomatic prostatic hypertrophy
• Bladder neck obstruction
• Pyloroduodenal obstruction
• Elderly, debilitated patients
• Have taken an MAOI in the past 14 days

Common side effects of Periactin:

• Sleepiness
• Dizziness
• Loss of coordination
• Confusion
• Blurred vision
• Low blood pressure
• Difficulty urinating
• Dryness of nose, throat, and mouth

Serious side effects are rare with Periactin. Contact your healthcare provider immediately if you experience any of the following.

• Signs of overdose: hallucinations, slow brain function, seizures, fast heartbeat, wide pupils, breathing problems
  Excessive sleepiness or dizziness

The following medications may interact with Periactin:

• MAO inhibitors prolong and intensify the anticholinergic effects of antihistamines
• Antihistamines may have additive effects with alcohol and other CNS depressants, e.g., hypnotics, sedatives, tranquilizers, antianxiety agents

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Two studies in pregnant women, have not shown that Periactin increases the risk of abnormalities when
administered during the first, second and third trimesters of pregnancy. However, you should talk to your healthcare provider before taking this medication if you are pregnant.

• Cyproheptadine