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Osimertinib is available as a 40 mg and 80 mg oral tablet.

Osimertinib is an EGFR inhibitor that is used to treat:
Metastatic NSCLC with specific EGFR mutations as initial treatment or in those no longer responding to other oral EGFR inhibitors NSCLC with specific EGFR mutations (given after surgery to remove the entire tumor)

Osimertinib is an EGFR inhibitor, meaning it blocks the activity of EGFR. More specifically, it targets and blocks the cells with the mutated EGFR (the cancer cells). As a result, the cancer cells can’t grow and/or spread as well. Osimertinib is unique because sometimes it can still work in tumors that no longer respond well to treatment by other EGFR inhibitors.

The usual dose of Osimertinib is 80 mg by mouth once a day.

Osimertinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Osimertinib:

• Low white blood cell count
• Low platelets
• Low red blood cells
• Diarrhea
• Acne-like rash
• Muscle aches/pain
• Nail changes
• Dry skin
• Mouth blisters and pain
• Fatigue
• Cough

Serious side effects are rare with Osimertinib. Contact your healthcare provider immediately if you experience any of the following.

• Serious lung problems: sudden cough, fever, trouble breathing, tightness in chest
• Serious skin reactions: painful blisters, skin wounds, peeling skin, fever, muscle aches
• Serious heart problems: heart failure, fluid in the lungs, trouble breathing, swelling in the legs, severe fatigue
  Serious blood problems: sudden fatigue, bruising, bleeding, fever

The following medications may interact with Osimertinib:

• Strong CYP3A Inducers: Avoid concomitant use. If not possible, increase Osimertinib to 160 mg daily in patients receiving a strong CYP3A4 inducer

Various FDA-approved generic manufacturers

Osimertinib can harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with Osimertinib or think you may be pregnant.
Females who are able to become pregnant should have a pregnancy test before starting treatment with Osimertinib. You should use effective birth control (contraception) during treatment with Osimertinib and for 6 weeks after the final dose of Osimertinib. Males who have female partners that are able to become pregnant should use effective birth control during treatment with Osimertinib and for 4 months after the final dose of Osimertinib.

• Tagrisso