ORENCIA
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Manufactured by Bristol-Myers Squibb
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ORENCIA Uses, Side Effects, Interactions, Warnings & Dosing
What is ORENCIA?
ORENCIA is the brand name for abatacept and is available as a subcutaneous injection and an IV infusion.
What dosages is ORENCIA available in?
ORENCIA is available in one of the following:
- Intravenous Infusion 250 mg lyophilized powder in a single-dose vial.
Subcutaneous Use
- 50 mg/0.4 mL, 87.5 mg/0.7 mL, 125 mg/mL solution in single-dose prefilled syringe.
125 mg/mL solution in a single-dose prefilled ClickJect autoinjectors
What is ORENCIA used for?
ORENCIA is a biologic DMARD that is used to treat:
Moderate-to-severe rheumatoid arthritis (RA) in adults
Psoriatic arthritis (PsA) in adults Moderate-to-severe polyarticular juvenile idiopathic arthritis (pJIA) in children ages 2 years and older Prevention of short-term graft versus host disease (GVHD) in combination with a calcineurin inhibitor and methotrexate in adults and children ages 2 years and older
How does ORENCIA work?
ORENCIA is a biologic disease-modifying anti-rheumatic drug (DMARD). It blocks certain proteins and processes in cells, which lowers inflammation. This prevents specific types of arthritis from getting worse.
How do I take ORENCIA?
ORENCIA is dosed as follows:
- Rheumatoid arthritis and psoriatic arthritis in adults
- Intravenous (IV): Your provider will calculate the dose based on your body weight. The typical dose ranges from 500 mg to 1,000 mg infused IV every 2 weeks for 3 doses, then every month after that
- Under the skin injection: The typical dose is 125 mg injected under the skin once weekly
- Juvenile idiopathic arthritis
- Intravenous (IV): Your child’s provider will calculate tje dose based on their body weight. The typical dose is 10 mg/kg infused IV every 2 weeks for 2 doses, then every month after that. Children weighing 75 kg or more will be given the adult dose for arthritis
- Under the skin injection: Your child’s provider will calculate the dose based on your child’s body weight. The typical dose is injected under the skin once weekly
- Children weighing 10 kg to less than 25 kg: 50 mg
- Children weighing 25 kg to less than 50 kg: 87.5 mg
- Children weighing 50 kg or more: 125 mg
- Prevention graft-versus-host disease
- Your provider will calculate the dose based on your body weight and age. The typical dose ranges from 10 mg/kg to 15 mg/kg infused through the veins the day before transplant, then on Day 5, 14, and 28 after transplant.
Is it safe for me to take ORENCIA?
ORENCIA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
ORENCIA Common Side Effects
Common side effects of ORENCIA:
- Headache
- Sore throat, runny nose, or other cold-like symptoms
- Dizziness
- Cough
- Back pain
- High blood pressure
- Upset stomach
- Pain while urinating and other symptoms of an urinary tract infection
ORENCIA Serious Side Effects
Serious side effects are rare with ORENCIA. Contact your healthcare provider immediately if you experience any of the following.
- Serious infections: fever, tiredness, chills, cough, trouble breathing
- Serious allergic reaction: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing
Effects of other drugs, drug classes and over-the-counter products on ORENCIA
The following medications may interact with ORENCIA:
- Concomitant administration of a TNF antagonist with ORENCIA has been associated with an increased risk of serious infections and no significant additional efficacy over use of the TNF antagonists alone. Concurrent therapy with ORENCIA and TNF antagonists is not recommended
Who makes ORENCIA?
Bristol-Myers Squibb
Is ORENCIA safe in pregnancy?
It is not known if ORENCIA can harm your unborn baby. If you took ORENCIA during pregnancy, talk to your healthcare provider before your baby receives any vaccines.
There is a registry for pregnant women exposed to ORENCIA. The purpose of this registry is to check the health of the pregnant mother and her child. Women are encouraged to call the registry themselves or ask their healthcare provider to contact the registry for them by calling 1-877-311-8972.
What is the generic name for ORENCIA?
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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