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Onyda XR is an extended-release oral suspension used to treat ADHD.

Onyda XR is available as a 0.1 mg/1 mL extended-release oral suspension.

Onyda XR is a centrally acting alpha2-adrenergic agonist indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) as monotherapy or as adjunctive therapy to central nervous system (CNS) stimulant medications in pediatric patients 6 years of age and older.

Onyda XR works by stimulating α-2 adrenergic receptors in the brain and is from a class of medicines called α-2 adrenergic receptor agonists. The Onyda XR (clonidine) mechanism of action on ADHD is unknown.

Onyda XR is started at 0.1 mg by mouth once daily at bedtime with or without food. The dosage may be increased in increments of 0.1 mg per day at weekly intervals. Maximum recommended dosage is 0.4 mg once daily at bedtime.

Onyda XR is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are allergic to clonidine or any of the inactive ingredients in the product.

Common side effects of Onyda XR: Sleepiness Fatigue Irritability, Nightmares Insomnia Constipation Dry mouth

Serious side effects are rare with Onyda XR. Contact your healthcare provider immediately if you experience any of the following: Low blood pressure/heartrate: dizziness, tiredness, or run out of breath easily Allergic reaction: can range from a mild rash to a more serious reaction such as swelling of the face or throat

The following medications may interact with Onyda XR: CNS Depressants: Clonidine may potentiate the CNS-depressive effects of alcohol, barbiturates or other sedating drugs. Tricyclic Antidepressants: May reduce the hypotensive effect of clonidine. Drugs Known to Affect Sinus Node Function or AV Nodal Conduction: Avoid use of Onyda XR with agents known to affect sinus node function or AV nodal conduction (e.g., digitalis, calcium channel blockers and betablockers) due to a potential for additive effects such as bradycardia and AV block. Antihypertensive drugs: Use caution when coadministered with Onyda XR.

Tris Pharma, Inc.

It is not known whether Onyda will harm your unborn baby. Talk with your healthcare provider about the risks of taking this medication if you are pregnant or plan on becoming pregnant.

• Clonidine Hydrochloride