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Onureg is the brand name for azacitidine and is available as an oral tablet.

Onureg is available as a 200 mg and 300 mg oral tablet.

Onureg is an antimetabolite that is used to treat acute myeloid leukemia maintenance treatment in adults.

Onureg is a chemotherapy medication called a hypomethylating agent. It works by inserting itself in the genetic material of cancer cells. By doing this, it turns on certain genes that help kill cancer cells. As a result, AML cells no longer grow out of control.

Onureg is dosed as follows:

• Acute myeloid leukemia
• Each chemotherapy cycle with Onureg (azacitidine) lasts about 1 month (28 days)
• Days 1-14: The typical dose is to take 300 mg by mouth daily
• Days 15-28: Don’t take any Onureg (azacitidine).
• Repeat chemotherapy cycle

Your dose of Onureg might be different if you experience certain side effects.

Onureg is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Onureg:

• Low white blood cells
• Nausea
• Low platelets
• Vomiting
• Diarrhea
• Tiredness or weakness
• Constipation
• Fever, cough, and other symptoms of pneumonia
• Low red blood cells
• Stomach pain

Serious side effects are rare with Onureg. Contact your healthcare provider immediately if you experience any of the following.

• Serious infections: fever, headache, chills, extreme tiredness, low energy, muscle aches, cough, sore throat, congestion
• Serious bleeding: unusual bruising or bleeding, bleeding that takes longer to stop, bleeding from the nose or gums, black or tarry stool

There are no major drug interactions listed for Onureg. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Bristol-Myers Squibb

Onureg can harm your unborn baby.
Females who are able to become pregnant:

• Your healthcare provider should perform a pregnancy test before you start treatment with Onureg.
  You should use effective birth control (contraception) during treatment and for at least 6 months after your last dose of Onureg. Tell your healthcare provider right away if you become pregnant during treatment with Onureg.

Males with a female sexual partner who can become pregnant:

• You should use effective birth control (contraception) during treatment and for at least 3 months after your last
  dose of Onureg.

• Azactidine Tablets