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Nyvepria is the brand name for pegfilgrastim-apgf and is available and is available as a subcutaneous injection.

Nyvepria is available as a 6 mg/0.6 mL solution in a single-dose prefilled syringe.

Nyvepria is a colony-stimulating factor and is used for the following:

• Infection prevention in people with certain cancers receiving anticancer medications that can cause low white blood cells (or febrile neutropenia)
• Increase survival in people exposed to bone marrow-suppressing radiation (Neulasta only)

Nyvepria is a granulocyte colony-stimulating factor (G-CSF). It works like the G-CSF protein that you naturally have in your body. G-CSF stimulates (triggers) your bone marrow to make neutrophils, a type of white blood cell that helps your body fight infections.

Patients with cancer receiving myelosuppressive chemotherapy

• 6 mg administered subcutaneously once per chemotherapy cycle. (2.1)
• Do not administer between 14 days before and 24 hours after administration of cytotoxic chemotherapy

Nyvepria is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are a patient with a history of serious allergic reactions to human granulocyte colony-stimulating factors such as pegfilgrastim products or filgrastim products.

Common side effects of Nyvepria:

• Bone pain
• Pain in arms and legs

Serious side effects are rare with Nyvepria. Contact your healthcare provider immediately if you experience any of the following.

• Shortness of breath or trouble breathing
• Ruptured spleen: pain in your left upper stomach or shoulder
• Serious allergic reaction: rash, trouble breathing, swelling of your tongue, lips, or throat

There are no major drug interactions listed for Nyvepria. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Pfizer Inc.

It is not known if Nyvepria harms your unborn baby. Nyvepria should be given to a pregnant woman only if clearly needed. Talk to your doctor about stopping NORPACE CR if you
are pregnant or planning to become pregnant.

• Pegfilgrastim-APGF