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Nintedanib is available as a 100 mg and 150 mg oral capsule.

Nintedanib is a tyrosine kinase inhibitor and is used for the following:

• Idiopathic pulmonary fibrosis
• Progressive fibrosing ILD
• Systemic sclerosis-associated ILD

Nintedanib is a tyrosine kinase inhibitor, meaning it blocks a protein called tyrosine kinase. This protein is involved in making scar tissue in your lungs. By blocking its activity, Nintedanib can treat scarring in the lungs from certain types of interstitial lung disease. This helps lower the lung symptoms you have, such as shortness of breath and cough.

• Nintedanib is typically dosed as 150 mg taken by mouth twice daily, 12 hours apart
• Your dose will be different if you have liver problems

Nintedanib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Nintedanib:

• Diarrhea
• Nausea
• Stomach pain
• Vomiting
• Elevated liver enzymes
• Fatigue
• Weight loss
• Headache
• Fever
• Back pain
• Dizziness
• High blood pressure

Serious side effects are rare with Nintedanib. Contact your healthcare provider immediately if you experience any of the following.

• Liver problems or liver failure: yellowing of your skin or the whites of your eyes, confusion, fatigue, low appetite, nausea, stomach discomfort, vomiting
• Heart attack: chest pain, short of breath, pain in the jaw, neck, or back, feeling weak or light-headed
• Blood clots in other parts of the body: chest pain, difficulty breathing, weakness, numbness or tingling sensation in arms and legs
• Serious bleeds: bleeds that are difficult to stop, bruises that don’t go away, weakness, tiredness, headaches, dizziness, bloody stool or blood in the urine
• Severe damage to stomach or intestines: sudden and severe pain or tenderness in stomach area, bloating, nausea, vomiting, bleeding in the rectum, change in appetite

The following medications may interact with Nintedanib:

• Coadministration of P-gp and CYP3A4 inhibitors may increase Nintedanib exposure
• Monitor patients closely for tolerability of Nintedanib

Various FDA-approved generic manufacturers

Based on findings from animal studies and its mechanism of action, Nintedanib can cause fetal harm when administered to a pregnant woman. You should avoid becoming pregnant while receiving treatment with Nintedanib and use highly effective contraception at initiation of, during treatment, and at least 3 months after the last dose of Nintedanib.

• Ofev