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Neulasta Onpro Kit is the brand name for pegfilgrastim subcutaneous injection.

Neulasta Onpro Kit is available as a 6 mg/0.6 mL solution.

Neulasta Onpro Kit is a leukocyte growth factor used to:
Decrease the incidence of infection, as manifested by febrile
neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia. Increase survival in patients acutely exposed to myelosuppressive doses
of radiation (Hematopoietic Subsyndrome of Acute Radiation
Syndrome).

Neulasta Onpro Kit is a granulocyte colony-stimulating factor (G-CSF). It works like the G-CSF protein that you naturally have in your body. G-CSF stimulates (triggers) your bone marrow to make neutrophils, a type of white blood cell that helps your body fight infections.

Neulasta Onpro Kit is dosed as follows:

• People receiving bone marrow-suppressing chemotherapy
• Adults and children weighing 99 lbs or more: The typical dose is 6 mg injected under the skin (subcutaneously) once per chemotherapy cycle. Please see the FAQ section for more details
• Children who weigh less than 99 lbs: Dosing will depend on the child’s weight
• People exposed to bone marrow-suppressing radiation (Neulasta only)
• Adults and children weighing 99 lbs or more The typical dose is 6 mg injected under the skin as soon as possible, followed by another 6 mg one week later
• Children who weigh less than 99 lbs: Dosing will depend on the child’s weight

Neulasta Onpro Kit is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a history of serious allergic reactions to human granulocyte colony-stimulating factors such as pegfilgrastim or filgrastim.

Common side effects of Neulasta Onpro Kit:

• Bone pain
• Pain in arms and legs
• Injection site reaction

Serious side effects are rare with Neulasta Onpro Kit. Contact your healthcare provider immediately if you experience any of the following.

• Shortness of breath or trouble breathing
• Ruptured spleen: pain in your left upper stomach or shoulder
• Serious allergic reaction: rash, trouble breathing, swelling of your tongue, lips, or throat

There are no major drug interactions listed for Neulasta Onpro Kit. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

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It is not known if Neulasta Onpro Kit may harm your unborn baby. Talk to your healthcare provider about possible pregnancy and birth control choices that are right for you.

• Pegfilgrastim