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Memantine /Donepezil is available as an oral capsule that contains one of the following:

• 14 mg memantine hydrochloride extended-release and 10 mg donepezil hydrochloride
• 28 mg memantine hydrochloride extended-release and 10 mg donepezil hydrochloride

Memantine /Donepezil is a NMDA antagonist / Acetylcholinesterase inhibitor and is used to treat moderate-to-severe dementia in people with Alzheimer’s disease (AD).

Memantine /Donepezil is a combination of two medications that treats moderate-to-severe dementia in people with Alzheimer’s disease. Memantine (an NMDA antagonist) lowers the activity of certain proteins in your brain. Donepezil (an acetylcholinesterase inhibitor) raises the levels of acetylcholine in the brain. These two medications work together to lower the symptoms of Alzheimer’s.

Memantine /Donepezil is dosed as follows:

• If your condition is stable on donepezil only: The typical starting dose is 7 mg/10 mg (memantine/donepezil) by mouth once per day in the evening. Your dose will be slowly raised in 7 mg increments until you reach 28 mg/10 mg (memantine/donepezil) once per day
• If your condition is stable on both donepezil and memantine (separately): The typical starting dose is 28 mg/10 mg (memantine/donepezil) by mouth once per day in the evening

Your dose may differ if you have kidney problems.

Memantine /Donepezil is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Memantine /Donepezil is contraindicated in patients with known hypersensitivity to
memantine hydrochloride, donepezil hydrochloride, piperidine derivatives, or to any excipients used in the formulation.

Common side effects of Memantine /Donepezil:

• Headache
• Diarrhea
• Nausea
• Vomiting
• Dizziness
• Loss of appetite (anorexia)
• Bruising

Serious side effects are rare with Memantine /Donepezil. Contact your healthcare provider immediately if you experience any of the following.

• Chest pain
• Seizure
• Slow heartbeat: fainting
• Stomach ulcers and bleeding: worsening upset stomach, heartburn, indigestion

The following medications may interact with Memantine /Donepezil:

• Combined use with NMDA antagonists: use with caution.
• Memantine /Donepezil may interfere with anticholinergic medications
• Concomitant administration of succinylcholine, similar neuromuscular blocking agents, or cholinergic agonists may lead to synergistic effect

Various FDA-approved generic manufacturers

It is not known if Memantine /Donepezil can harm an unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Namzaric