memantine /donepezil
Used for Dementia
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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memantine /donepezil Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is memantine /donepezil available in?
memantine /donepezil is available as an oral capsule that contains one of the following:
- 14 mg memantine hydrochloride extended-release and 10 mg donepezil hydrochloride
- 28 mg memantine hydrochloride extended-release and 10 mg donepezil hydrochloride
What is memantine /donepezil used for?
memantine /donepezil is a NMDA antagonist / Acetylcholinesterase inhibitor and is used to treat moderate-to-severe dementia in people with Alzheimer’s disease (AD).
How does memantine /donepezil work?
memantine /donepezil is a combination of two medications that treats moderate-to-severe dementia in people with Alzheimer’s disease. Memantine (an NMDA antagonist) lowers the activity of certain proteins in your brain. Donepezil (an acetylcholinesterase inhibitor) raises the levels of acetylcholine in the brain. These two medications work together to lower the symptoms of Alzheimer’s.
How do I take memantine /donepezil?
memantine /donepezil is dosed as follows:
- If your condition is stable on donepezil only: The typical starting dose is 7 mg/10 mg (memantine/donepezil) by mouth once per day in the evening. Your dose will be slowly raised in 7 mg increments until you reach 28 mg/10 mg (memantine/donepezil) once per day
- If your condition is stable on both donepezil and memantine (separately): The typical starting dose is 28 mg/10 mg (memantine/donepezil) by mouth once per day in the evening
Your dose may differ if you have kidney problems.
Is it safe for me to take memantine /donepezil?
memantine /donepezil is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. memantine /donepezil is contraindicated in patients with known hypersensitivity to
memantine hydrochloride, donepezil hydrochloride, piperidine derivatives, or to any excipients used in the formulation.
memantine /donepezil Common Side Effects
Common side effects of memantine /donepezil:
- Headache
- Diarrhea
- Nausea
- Vomiting
- Dizziness
- Loss of appetite (anorexia)
- Bruising
memantine /donepezil Serious Side Effects
Serious side effects are rare with memantine /donepezil. Contact your healthcare provider immediately if you experience any of the following.
- Chest pain
- Seizure
- Slow heartbeat: fainting
- Stomach ulcers and bleeding: worsening upset stomach, heartburn, indigestion
Effects of other drugs, drug classes and over-the-counter products on memantine /donepezil
The following medications may interact with memantine /donepezil:
- Combined use with NMDA antagonists: use with caution.
- memantine /donepezil may interfere with anticholinergic medications
- Concomitant administration of succinylcholine, similar neuromuscular blocking agents, or cholinergic agonists may lead to synergistic effect
Who makes memantine /donepezil?
Various FDA-approved generic manufacturers
Is memantine /donepezil safe in pregnancy?
It is not known if memantine /donepezil can harm an unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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