MEKTOVI
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Manufactured by Pfizer
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MEKTOVI Uses, Side Effects, Interactions, Warnings & Dosing
What is MEKTOVI?
MEKTOVI is the brand name for binimetinib and is available as an oral tablet.
What dosages is MEKTOVI available in?
MEKTOVI is available as a 15 mg oral tablet.
What is MEKTOVI used for?
MEKTOVI is a MEK inhibitor and is used for the following:
Melanoma with certain BRAF mutations that has spread (metastatic) or can’t be removed by surgery; used with Braftovi (encorafenib) Metastatic non-small cell lung cancer (NSCLC) with certain BRAF mutations; used with Braftovi (encorafenib)
How does MEKTOVI work?
MEKTOVI is a kinase inhibitor known as a MEK inhibitor. The MEK protein is part of a whole chain of proteins that help cells grow. By blocking MEK, this medication helps stop tumor growth. MEKTOVI is taken together with an anticancer medication called Braftovi (encorafenib) that specifically targets another protein in this chain (the BRAF protein). When the BRAF protein is mutated, the cancer grows uncontrollably and can spread more quickly. By blocking two different proteins in this pathway, MEKTOVI and Braftovi (encorafenib) work together to stop the cancer from growing and spreading.
How do I take MEKTOVI?
MEKTOVI is typically dosed at 45 mg by mouth twice a day (about 12 hours apart). Your dose might differ if you have moderate or severe liver problems. Your provider might also recommend taking a lower dose if you have certain side effects.
Is it safe for me to take MEKTOVI?
MEKTOVI is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
MEKTOVI Common Side Effects
Common side effects of MEKTOVI:
- Higher creatinine levels in the blood
- Higher liver enzymes in the blood
- Tiredness
- Nausea
- Diarrhea
- Anemia
- Vomiting
- Stomach pain
- Constipation
- Rash
- Vision changes
MEKTOVI Serious Side Effects
Serious side effects are rare with MEKTOVI. Contact your healthcare provider immediately if you experience any of the following.
- Blood clots: sudden trouble breathing; chest pain; swelling in one arm or one leg, often with warm, red skin
- Serious lung problems: sudden cough, trouble breathing, tightness in chest, fever
- Bleeding: blood in stool, bleeding from rectum, sudden headache
Effects of other drugs, drug classes and over-the-counter products on MEKTOVI
There are no major drug interactions listed for MEKTOVI. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Who makes MEKTOVI?
Pfizer
Is MEKTOVI safe in pregnancy?
MEKTOVI can harm your unborn baby. Females who are able to become pregnant should use effective birth control (contraception) during treatment with MEKTOVI and for at least 30 days after the last dose of MEKTOVI. Talk to your healthcare provider about birth control methods that may be right for you during this time. Your healthcare provider will do a pregnancy test before you start taking MEKTOVI. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with MEKTOVI.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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