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Binimetinib is available as a 15 mg oral tablet.

Binimetinib is a MEK inhibitor and is used for the following:
Melanoma with certain BRAF mutations that has spread (metastatic) or can’t be removed by surgery; used with Braftovi (encorafenib) Metastatic non-small cell lung cancer (NSCLC) with certain BRAF mutations; used with Braftovi (encorafenib)

Binimetinib is a kinase inhibitor known as a MEK inhibitor. The MEK protein is part of a whole chain of proteins that help cells grow. By blocking MEK, this medication helps stop tumor growth. Binimetinib is taken together with an anticancer medication called Braftovi (encorafenib) that specifically targets another protein in this chain (the BRAF protein). When the BRAF protein is mutated, the cancer grows uncontrollably and can spread more quickly. By blocking two different proteins in this pathway, Binimetinib and Braftovi (encorafenib) work together to stop the cancer from growing and spreading.

Binimetinib is typically dosed at 45 mg by mouth twice a day (about 12 hours apart). Your dose might differ if you have moderate or severe liver problems. Your provider might also recommend taking a lower dose if you have certain side effects.

Binimetinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Binimetinib:

• Higher creatinine levels in the blood
• Higher liver enzymes in the blood
• Tiredness
• Nausea
• Diarrhea
• Anemia
• Vomiting
• Stomach pain
• Constipation
• Rash
• Vision changes

Serious side effects are rare with Binimetinib. Contact your healthcare provider immediately if you experience any of the following.

• Blood clots: sudden trouble breathing; chest pain; swelling in one arm or one leg, often with warm, red skin
• Serious lung problems: sudden cough, trouble breathing, tightness in chest, fever
• Bleeding: blood in stool, bleeding from rectum, sudden headache

There are no major drug interactions listed for Binimetinib. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

Binimetinib can harm your unborn baby. Females who are able to become pregnant should use effective birth control (contraception) during treatment with Binimetinib and for at least 30 days after the last dose of Binimetinib. Talk to your healthcare provider about birth control methods that may be right for you during this time. Your healthcare provider will do a pregnancy test before you start taking Binimetinib. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with Binimetinib.

• Mektovi