binimetinib
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Manufactured by various FDA-approved generic manufacturers.
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binimetinib Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is binimetinib available in?
binimetinib is available as a 15 mg oral tablet.
What is binimetinib used for?
binimetinib is a MEK inhibitor and is used for the following:
Melanoma with certain BRAF mutations that has spread (metastatic) or can’t be removed by surgery; used with Braftovi (encorafenib) Metastatic non-small cell lung cancer (NSCLC) with certain BRAF mutations; used with Braftovi (encorafenib)
How does binimetinib work?
binimetinib is a kinase inhibitor known as a MEK inhibitor. The MEK protein is part of a whole chain of proteins that help cells grow. By blocking MEK, this medication helps stop tumor growth. binimetinib is taken together with an anticancer medication called Braftovi (encorafenib) that specifically targets another protein in this chain (the BRAF protein). When the BRAF protein is mutated, the cancer grows uncontrollably and can spread more quickly. By blocking two different proteins in this pathway, binimetinib and Braftovi (encorafenib) work together to stop the cancer from growing and spreading.
How do I take binimetinib?
binimetinib is typically dosed at 45 mg by mouth twice a day (about 12 hours apart). Your dose might differ if you have moderate or severe liver problems. Your provider might also recommend taking a lower dose if you have certain side effects.
Is it safe for me to take binimetinib?
binimetinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
binimetinib Common Side Effects
Common side effects of binimetinib:
- Higher creatinine levels in the blood
- Higher liver enzymes in the blood
- Tiredness
- Nausea
- Diarrhea
- Anemia
- Vomiting
- Stomach pain
- Constipation
- Rash
- Vision changes
binimetinib Serious Side Effects
Serious side effects are rare with binimetinib. Contact your healthcare provider immediately if you experience any of the following.
- Blood clots: sudden trouble breathing; chest pain; swelling in one arm or one leg, often with warm, red skin
- Serious lung problems: sudden cough, trouble breathing, tightness in chest, fever
- Bleeding: blood in stool, bleeding from rectum, sudden headache
Effects of other drugs, drug classes and over-the-counter products on binimetinib
There are no major drug interactions listed for binimetinib. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Who makes binimetinib?
Various FDA-approved generic manufacturers
Is binimetinib safe in pregnancy?
binimetinib can harm your unborn baby. Females who are able to become pregnant should use effective birth control (contraception) during treatment with binimetinib and for at least 30 days after the last dose of binimetinib. Talk to your healthcare provider about birth control methods that may be right for you during this time. Your healthcare provider will do a pregnancy test before you start taking binimetinib. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with binimetinib.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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