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Mavacamten is available as a 2.5, 5, 10, or 15 mg immediate release capsule formulation.

Mavacamten is a cardiac myosin inhibitor.

Mavacamten works by blocking the activity of a certain protein that is involved in helping the heart muscle contract. Therefore, by blocking the protein, Mavacamten relaxes the heart muscle.

Mavacamten is prescribed to be taken once a day, swalloed whole. Before you are first prescribed Mavacamten, your healthcare provider will do an echocardiogram (echo) to assess your obstructive HCM.

Mavacamten is a safe and effective treatment when used for FDA-licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Mavacamten include:

• Dizziness
• Fainting (syncope)

Serious side effects are rare with Mavacamten. However, If you do notice symptoms of shortness of breath, chest pain, fatigue
racing heart (palpitations), leg swelling, rapid weight gain then you should contact your physician as a matter of urgency. This could be a sign of heart failure (a condition where the heart cannot pump with enough force).

The following medications may interact with Mavacamten:

• Apalutamide
• Aprepitant
• Antifungals (e.g., fluconazole, itraconazole, ketoconazole)
• Beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
• Bosentan
• Cannabidiol
• Cimetidine.

Various FDA-approved generic manufacturers

Animal studies have shown there is risk to the foetus. Mavacamten is therefore contraindicated during pregnancy and in women of childbearing potential not using effective contraception.

• Camzyos