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Camzyos is the brand name medication for the drug mavacamten. It is the first and only FDA-approved cardiac myosin inhibitor that specifically targets the source of obstructive hypertrophic cardiomyopathy (HCM).

Camzyos is available as a 2.5, 5, 10, or 15 mg immediate release capsule formulation.

Camzyos is a cardiac myosin inhibitor.

Camzyos works by blocking the activity of a certain protein that is involved in helping the heart muscle contract. Therefore, by blocking the protein, Camzyos relaxes the heart muscle.

Camzyos is prescribed to be taken once a day, swalloed whole. Before you are first prescribed Camzyos, your healthcare provider will do an echocardiogram (echo) to assess your obstructive HCM.

Camzyos is a safe and effective treatment when used for FDA-licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Camzyos include:

• Dizziness
• Fainting (syncope)

Serious side effects are rare with Camzyos. However, If you do notice symptoms of shortness of breath, chest pain, fatigue
racing heart (palpitations), leg swelling, rapid weight gain then you should contact your physician as a matter of urgency. This could be a sign of heart failure (a condition where the heart cannot pump with enough force).

The following medications may interact with Camzyos:

• Apalutamide
• Aprepitant
• Antifungals (e.g., fluconazole, itraconazole, ketoconazole)
• Beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
• Bosentan
• Cannabidiol
• Cimetidine.

Bristol-Myers Squibb

Animal studies have shown there is risk to the foetus. Camzyos is therefore contraindicated during pregnancy and in women of childbearing potential not using effective contraception.

• Mavacamten