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Lyumjev is the brand name for insulin lispro-aabc and is available as an injection for subcutaneous or IV use.

Lyumjev is available as a Kwikpen, Junior Kwikpen, Tempo Pen, vial, and cartridge that contain 100 units/ml as well as a Kwikpen that contains 200 units/ml.

Lyumjev is an insulin and is used for the following:

• Type 1 diabetes
• Type 2 diabetes

Lyumjev is an insulin. Insulin is a natural hormone your body normally makes to lower glucose (sugar) levels in the blood. It helps your body absorb and store sugar from your bloodstream after eating a meal. It also stops your liver from making glucose.

• The dose of Lyumjev will be different for each person. The dose depends on whether you’re using it for type 1 diabetes or type 2 diabetes, your weight, how well you respond to insulin, your blood sugar levels, and if you’re administering the medication through an injection or through a continuous insulin pump. Your healthcare provider will determine the dose that works best for you
• Injection: Lyumjev is typically injected under the skin (subcutaneously) at the start of a meal or within 20 minutes after starting a meal
• Continuous insulin pump (for Lyumjev U-100 only): Refer to the instructions from your insulin pump manufacturer. Don’t use Lyumjev U-200 in an insulin pump

Lyumjev is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have symptoms of hypoglycemia.

Common side effects of Lyumjev:

• Low blood sugar
• Allergic reactions
• Injection site reactions (e.g., swelling, pain, redness)
• Lumps in the skin or thickened skin where the medication is injected
• Weight gain
• Rash
• Itchy skin

Serious side effects are rare with Lyumjev. Contact your healthcare provider immediately if you experience any of the following.

• Severe hypoglycemia (dangerously low blood sugar): if not treated, severe hypoglycemia can lead to unconsciousness, seizures, and even death
• Severe allergic reactions: rash, hives, swelling of face, tongue, and throat, difficulty breathing
• Dangerously low levels of potassium: if not treated, it can lead to difficulty breathing, irregular heartbeat, and even death

The following medications may interact with Lyumjev:

• Drugs that Increase Hypoglycemia Risk or Increase or Decrease
• Blood Glucose Lowering Effect: Adjustment of dosage may be needed; closely monitor blood glucose
• Drugs that Blunt Hypoglycemia Signs and Symptoms (e.g., betablockers, clonidine, guanethidine, and reserpine): Increased frequency of glucose monitoring may be required

Eli Lilly & Company

Published studies with Lyumjev used during pregnancy have not reported an association between insulin lispro and
the induction of major birth defects, miscarriage, or adverse maternal or fetal outcomes. If you become pregnant while receiving Lyumjev, talk to your healthcare provider.

• Insulin Lispro-AABC