Used for Cancer

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

LORBRENA Uses, Side Effects, Interactions, Warnings & Dosing



LORBRENA is the brand name for lorlatinib and is available and an oral tablet.

What dosages is LORBRENA available in?

What dosages is LORBRENA available in?

LORBRENA is available as a 25 mg and 100 mg oral tablet.

What is LORBRENA used for?

What is LORBRENA used for?

LORBRENA is a kinase inhibitor and is used to treat anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer that has spread to other parts of the body.

How does LORBRENA work?

How does LORBRENA work?

LORBRENA is a targeted therapy anticancer medication that blocks a protein called anaplastic lymphoma kinase (ALK). The ALK protein is made by the ALK gene. This gene is something that everyone is born with. In people with ALK-positive NSCLC, this gene doesn’t work like it should. It ends up making abnormal proteins and causing cancer. LORBENA works to block the ALK protein, so cancer cells can’t grow and spread as well.

How do I take LORBRENA?

How do I take LORBRENA?

LORBRENA is typically dosed at s 100 mg orally once daily.

Is it safe for me to take LORBRENA?

Is it safe for me to take LORBRENA?

LORBRENA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a strong CYP3A inducer.

LORBRENA Common Side Effects

LORBRENA Common Side Effects

Common side effects of LORBRENA:

  • High cholesterol and fat levels in blood
  • Abnormal kidney labs
  • Swelling in the eyelids, face, and hands and feet
  • Abnormal liver protein labs
  • Abnormal blood cell counts
  • High blood sugar
  • Nerve pain
  • Weight gain
  • Problems with memory and attention
  • Trouble breathing
  • Tiredness
  • Abnormal pancreas labs
  • Changes in mood
  • Joint pain
  • Diarrhea
  • Changes in electrolyte levels
LORBRENA Serious Side Effects

LORBRENA Serious Side Effects

Serious side effects are rare with LORBRENA. Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts and self-harm
  • Severe lung problems: new or worsening breathing problems (e.g., coughing or trouble breathing) or fever
  • Blocked heartbeat: feeling dizzy, faint, or a change in your heartbeat
Effects of other drugs, drug classes and over-the-counter products on LORBRENA

Effects of other drugs, drug classes and over-the-counter products on LORBRENA

The following medications may interact with LORBRENA:

  • CYP3A Inducers: Contraindicated with strong CYP3A inducers. Avoid concomitant use with moderate CYP3A inducers.
  • CYP3A Inhibitors: Avoid concomitant use with strong CYP3A inhibitors; reduce LORBRENA dose if concomitant use cannot be avoided
  • CYP3A Substrates: Avoid concomitant use with CYP3A substrates where minimal concentration changes may lead to serious therapeutic failures
Who makes LORBRENA?

Who makes LORBRENA?


Is LORBRENA safe in pregnancy?

Is LORBRENA safe in pregnancy?

LORBRENA can harm your unborn baby. Your healthcare provider will do a pregnancy test before you start treatment with LORBRENA. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with LORBRENA. Females who are able to become pregnant should use effective non-hormonal birth control during treatment with LORBRENA and for at least 6 months after the final dose of LORBRENA. Birth control pills
(oral contraceptives) and other hormonal forms of birth control may not be effective if used during treatment with LORBRENA. Talk to your healthcare provider about birth control choices that are right for you during this time.
Males who have female partners who are able to become pregnant should use effective birth control during treatment with LORBRENA and for at least 3 months after the final dose of LORBRENA.


What to do if you missed your LORBRENA dose

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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