lorlatinib
Used for Cancer
NowPatient helps you obtain your lorlatinib prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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lorlatinib key facts
What dosages is lorlatinib available in?
lorlatinib is available as a 25 mg and 100 mg oral tablet.
What is lorlatinib used for?
lorlatinib is a kinase inhibitor and is used to treat anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer that has spread to other parts of the body.
How does lorlatinib work?
lorlatinib is a targeted therapy anticancer medication that blocks a protein called anaplastic lymphoma kinase (ALK). The ALK protein is made by the ALK gene. This gene is something that everyone is born with. In people with ALK-positive NSCLC, this gene doesn’t work like it should. It ends up making abnormal proteins and causing cancer. LORBENA works to block the ALK protein, so cancer cells can’t grow and spread as well.
How do I take lorlatinib?
lorlatinib is typically dosed at s 100 mg orally once daily.
Is it safe for me to take lorlatinib?
lorlatinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a strong CYP3A inducer.
lorlatinib Common Side Effects
Common side effects of lorlatinib:
- High cholesterol and fat levels in blood
- Abnormal kidney labs
- Swelling in the eyelids, face, and hands and feet
- Abnormal liver protein labs
- Abnormal blood cell counts
- High blood sugar
- Nerve pain
- Weight gain
- Problems with memory and attention
- Trouble breathing
- Tiredness
- Abnormal pancreas labs
- Changes in mood
- Joint pain
- Diarrhea
- Changes in electrolyte levels
lorlatinib Serious Side Effects
Serious side effects are rare with lorlatinib. Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts and self-harm
- Severe lung problems: new or worsening breathing problems (e.g., coughing or trouble breathing) or fever
- Blocked heartbeat: feeling dizzy, faint, or a change in your heartbeat
Effects of other drugs, drug classes and over-the-counter products on lorlatinib
The following medications may interact with lorlatinib:
- CYP3A Inducers: Contraindicated with strong CYP3A inducers. Avoid concomitant use with moderate CYP3A inducers.
- CYP3A Inhibitors: Avoid concomitant use with strong CYP3A inhibitors; reduce lorlatinib dose if concomitant use cannot be avoided
- CYP3A Substrates: Avoid concomitant use with CYP3A substrates where minimal concentration changes may lead to serious therapeutic failures
Who makes lorlatinib?
Various FDA-approved generic manufacturers
Is lorlatinib safe in pregnancy?
lorlatinib can harm your unborn baby. Your healthcare provider will do a pregnancy test before you start treatment with lorlatinib. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with lorlatinib. Females who are able to become pregnant should use effective non-hormonal birth control during treatment with lorlatinib and for at least 6 months after the final dose of lorlatinib. Birth control pills
(oral contraceptives) and other hormonal forms of birth control may not be effective if used during treatment with lorlatinib. Talk to your healthcare provider about birth control choices that are right for you during this time.
Males who have female partners who are able to become pregnant should use effective birth control during treatment with lorlatinib and for at least 3 months after the final dose of lorlatinib.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my lorlatinib prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your lorlatinib prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient lorlatinib savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient lorlatinib savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for lorlatinib | Canadian Prescription Savings* for lorlatinib | lorlatinib Drug Coupon* | lorlatinib Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of lorlatinib?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for lorlatinib | Canadian Prescription Savings* for lorlatinib | lorlatinib Drug Coupon* | lorlatinib Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the lorlatinib savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the lorlatinib drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for lorlatinib, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the lorlatinib prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, lorlatinib is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed lorlatinib for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the lorlatinib prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the lorlatinib prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for lorlatinib
If you are having trouble paying for your lorlatinib medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for lorlatinib you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- lorlatinib is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers lorlatinib
- If lorlatinib is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for lorlatinib
If you are having trouble paying for your lorlatinib medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for lorlatinib you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers lorlatinib
- If lorlatinib is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for lorlatinib
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your lorlatinib treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for lorlatinib you will need to meet the following criteria:
- You must be currently insured and have coverage for lorlatinib
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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