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Isentress HD is the brand name for raltegravir and is available as an oral tablet.

Isentress HD is available as a 600 mg oral tablet.

Isentress HD is a HIV ARV and is used for the following:

• HIV treatment
• HIV post-exposure prophylaxis (PEP)

Isentress HD is an integrase inhibitor. Integrase is an enzyme that the HIV virus uses to enter your cells and make more copies of itself. When integrase is stopped, the virus cannot grow and spread.

Isentress HD is typically dosed as follows:

• Adults: The typical dose is 1 tablet (400 mg) twice daily OR for the HD tablet, 2 tablets (1200 mg) once daily
• Children: The dose is based on the child’s weight

Isentress HD is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Isentress HD:

• Headache
• Trouble sleeping
• Nausea

Serious side effects are rare with Isentress HD. Contact your healthcare provider immediately if you experience any of the following.

• Muscle pain/damage (rhabdomyolysis)
• Allergic or severe skin reaction (severe rash, face swelling, difficulty breathing)

The following medications may interact with Isentress HD:

• Coadministration of ISENTRESS or Isentress HD and other drugs may alter the plasma concentration of raltegravir. The potential for drug-drug interactions must be considered prior to and during therapy
• Coadministration of ISENTRESS or Isentress HD with drugs that are strong inducers of UGT1A1, such as rifampin, may result in reduced plasma concentrations of raltegravir

Merck & Co., Inc.

It is not known if Isentress HD can harm your unborn baby. Isentress HD should only be used during pregnancy if the benefit to you is worth the possible risk to your baby.
There is a pregnancy exposure registry that monitors pregnancy outcomes in women. Healthcare providers are encouraged to register patients by calling the Antiretroviral Pregnancy Registry (APR) at 1- 800-258-4263.

• Raltegravir