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A single dose of Idecabtagene Vicleucel contains a cell suspension of 300 to 510 x 106 CAR-positive T cells in one or more infusion bags.

Idecabtagene Vicleucel is used to treat advanced multiple myeloma in adults (after at least two or more prior therapies).

Idecabtagene Vicleucel is a type of immunotherapy, also called CAR-T therapy. During treatment, your T-cells are removed from your body and sent to a lab. They are then modified to find and attack the multiple myeloma cancer cells in your body. Then the T-cells are infused back into your body to destroy cancer cells.

You will be given a chemotherapy regimen of cyclophosphamide and fludarabine and also premedicated with acetaminophen and an H1-antihistamine before an infusion of Idecabtagene Vicleucel. You will then be receive an infusion of Idecabtagene Vicleucel within the recommended dose range is 300 to 510 × 106 CAR-positive T cells

Idecabtagene Vicleucel is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Idecabtagene Vicleucel include:

• Lower blood cell counts
• Cytokine release syndrome
• Infection
• Tiredness
• Lower blood phosphate levels
• Muscle pain
• Lower immunoglobulin levels
• Diarrhea
• Nausea
• Nervous system problems
• Fever
• Swelling
• Headache
• Cough
• Decreased appetite

Serious side effects are rare with Idecabtagene Vicleucel. Contact your healthcare provider immediately if you experience any of the following:

• Cytokine release syndrome: Fever, trouble breathing, chills, low blood pressure, changes in heart rhythm, headache
• Serious nervous system problems: headache, confusion, difficulty speaking, difficulty writing, seizures
• Infection: fever, body aches, fast heartbeat, chills
• Bleeding (from low platelet levels): nosebleeds, blood in urine, blood in stool, unexplained bruising

There are no major drug interactions listed for Idecabtagene Vicleucel. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Abecma