Are you tired of high medication costs? Our service offers unbeatable savings on your GLUCOPHAGE XR prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.

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*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

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GLUCOPHAGE XR Uses, Side Effects, Interactions, Warnings & Dosing



GLUCOPHAGE XR is the brand name for metformin and is available as an extended-release oral tablet.

What dosages is GLUCOPHAGE XR available in?

What dosages is GLUCOPHAGE XR available in?

GLUCOPHAGE XR is available as a 500 mg and 750 mg extended-release oral tablet.

What is GLUCOPHAGE XR used for?

What is GLUCOPHAGE XR used for?

GLUCOPHAGE XR is a biguanide that is used to treat type 2 diabetes.

How does GLUCOPHAGE XR work?

How does GLUCOPHAGE XR work?

GLUCOPHAGE XR is a biguanide, which uses many methods to lower your blood sugar. It lowers the amount of sugar your body makes and absorbs from food. It also helps your body respond better to insulin.

How do I take GLUCOPHAGE XR?

How do I take GLUCOPHAGE XR?

GLUCOPHAGE XR is typically taken by mouth with a starting dose is 500 mg with your evening meal. If needed, your provider might raise your dose as long as you’re not having bad side effects. The maximum total dose is 2,000 mg daily.

Is it safe for me to take GLUCOPHAGE XR?

Is it safe for me to take GLUCOPHAGE XR?

GLUCOPHAGE XR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have severe renal impairment (eGFR below 30 mL/min/1.73 m2), a hypersensitivity to metformin, or acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.

GLUCOPHAGE XR Common Side Effects

GLUCOPHAGE XR Common Side Effects

Common side effects of GLUCOPHAGE XR include:

  • Diarrhea
  • Nausea and vomiting
  • Stomach pain
  • Constipation
  • Bloating
  • Heartburn
  • Gas
  • Dizziness
  • Headache
GLUCOPHAGE XR Serious Side Effects

GLUCOPHAGE XR Serious Side Effects

Serious side effects are rare with GLUCOPHAGE XR. Contact your healthcare provider immediately if you experience any of the following.

  • Lactic acidosis: muscle pain, severe abdominal pain, shallow breathing, tiredness, weakness, change in heartbeat
Effects of other drugs, drug classes and over-the-counter products on GLUCOPHAGE XR

Effects of other drugs, drug classes and over-the-counter products on GLUCOPHAGE XR

The following medications may interact with GLUCOPHAGE XR:

  • Carbonic anhydrase inhibitors – May increase risk of lactic acidosis
  • Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine) – May increase the accumulation of metformin
  • Alcohol – Can potentiate the effect of metformin on lactate metabolism


Bristol-Myers Squibb

Is GLUCOPHAGE XR safe in pregnancy?

Is GLUCOPHAGE XR safe in pregnancy?

It is not known if GLUCOPHAGE XR will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.


What to do if you missed your GLUCOPHAGE XR dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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