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Eflornithine is available as a 192 mg oral tablet.

Eflornithine is an ornithine decarboxylase inhibitor indicated to reduce the risk of relapse in adult and pediatric patients with high-risk neuroblastoma (HRNB) who have demonstrated at least a partial response to prior treatment with other agents, including anti-GD2 immunotherapy.

Eflornithine works by blocking an enzyme called ornithine decarboxylase (ODC). This action disrupts the production of polyamines, which are substances essential for the growth and proliferation of cancer cells, particularly in neuroblastoma tumors.

Eflornithine is dosed based on body surface area. It is typically taken by mouth twice daily with or without food until disease progression, unacceptable toxicity, or for a maximum of two years.

Eflornithine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Eflornithine:

• Hearing loss
• Ear infections
• Fever
• Pneumonia
• Diarrhea
• Laboratory abnormalities

Serious side effects are rare with Eflornithine. Contact your healthcare provider immediately if you experience any of the following:

• Low blood cell counts: fever (temperature 100.4°F or higher), feeling unusually tired or weak, easy bruising or bleeding, shortness of breath, blood in your urine or stools, and chills
• Liver problems: yellowing of your skin or the white part of your eyes (jaundice), nausea or vomiting, easy bruising or bleeding, dark colored urine, loss of appetite, light-colored stools, right side abdominal pain

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

Eflornithine can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant. Females who can get pregnant should have a pregnancy test before starting treatment. You should use effective birth control during treatment and for 1 week after the last dose. Males who have female partners that can get pregnant should use effective birth control during treatment and for 1 week after the last dose.

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