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Edurant is the brand name for rilpivirine and is available as an oral tablet.

Edurant is available as a 25 mg oral tablet.

Edurant is a HIV ARV and is used for the following:

• Treatment of HIV-1 infection in people with an HIV viral load of less than 100,000 copies/mL and who haven’t taken HIV medications before
• Short-term treatment of HIV-1 infection in certain people who are planning to start or planning to miss a dose of Cabenuva (cabotegravir / rilpivirine)

Edurant is an HIV antiretroviral medication that’s known as a non-nucleoside reverse transcriptase inhibitor (NNRTI). It blocks an enzyme called reverse transcriptase that helps HIV make copies of itself. By blocking this enzyme, the medication prevents HIV from spreading.

Edurant is dosed as follows:

• Treatment of HIV-1: The typical dose is 25 mg by mouth once a day with a meal. Edurant is taken with other antiretroviral medications
• Short-term treatment of HIV-1 before starting Cabunuva (cabotegravir / rilpivirine): The typical dose is 25 mg by mouth once a day with a meal for about 1 month (at least 28 days). It’s taken together with Vocabria (cabotegravir)
• Replacing a missed injection of Cabenuva (cabotegravir / rilpivirine): Your HIV specialist might prescribe Edurant for you to take for a short while if you’re getting Cabenuva injections for HIV but will miss an injection because of a schedule conflict (e.g., traveling). The typical dose of Edurant is 25 mg by mouth once a day with a meal and with Vocabria (cabotegravir). This combination is only meant to be taken for up to 2 months to replace missed injections

Edurant is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you take any medications that can greatly lower the amount of Edurant in your body, such as certain anti-seizure medications (e.g., carbamazepine (Tegretol)), certain antibiotics (e.g., rifampin (Rifadin)), more than a single dose of dexamethasone, or St. John’s wort

Common side effects of Edurant:

• Higher liver function tests
• Higher cholesterol levels
• Higher creatinine levels
• Feeling depressed
• Headache
• Trouble sleeping
• Rash

Serious side effects are rare with Edurant. Contact your healthcare provider immediately if you experience any of the following.

• Suicidal thoughts and behaviors
• Serious allergic reactions: mouth sores; trouble breathing; rash; fever; swelling in your face, lips, or tongue
• Liver problems: upper right stomach pain, nausea, yellowing of the skin or whites of the eyes, dark urine

The following medications may interact with Edurant:

• Consider alternatives to Edurant or Edurant PED when coadministered with drugs with a known risk of torsade de pointes
• Edurant and Edurant PED should not be used in combination with NNRTIs
• Coadministration of Edurant or Edurant PED with drugs that induce or inhibit CYP3A may affect the plasma concentrations of rilpivirine
• Coadministration of Edurant or Edurant PED with drugs that increase gastric pH may decrease plasma concentrations of rilpivirine
• Refer to the Full Prescribing Information for other drugs that should not be coadministered with Edurant or Edurant PED and for other drugs that may require a change in dose or regimen

Janssen Pharmaceuticals

It is not known if Edurant will harm your unborn baby. If you become pregnant while receiving Edurant, talk to your healthcare provider. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to
Edurant during pregnancy. Healthcare providers are encouraged to register patients by calling the Antiretroviral Pregnancy Registry (APR) 1-800-258-4263.

• Rilpivirine