rilpivirine
Used for HIV
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Manufactured by various FDA-approved generic manufacturers.
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Useful information about rilpivirine
What dosages is rilpivirine available in?
rilpivirine is available as a 25 mg oral tablet.
What is rilpivirine used for?
rilpivirine is a HIV ARV and is used for the following:
- Treatment of HIV-1 infection in people with an HIV viral load of less than 100,000 copies/mL and who haven’t taken HIV medications before
- Short-term treatment of HIV-1 infection in certain people who are planning to start or planning to miss a dose of Cabenuva (cabotegravir / rilpivirine)
How does rilpivirine work?
rilpivirine is an HIV antiretroviral medication that’s known as a non-nucleoside reverse transcriptase inhibitor (NNRTI). It blocks an enzyme called reverse transcriptase that helps HIV make copies of itself. By blocking this enzyme, the medication prevents HIV from spreading.
How do I take rilpivirine?
rilpivirine is dosed as follows:
- Treatment of HIV-1: The typical dose is 25 mg by mouth once a day with a meal. rilpivirine is taken with other antiretroviral medications
- Short-term treatment of HIV-1 before starting Cabunuva (cabotegravir / rilpivirine): The typical dose is 25 mg by mouth once a day with a meal for about 1 month (at least 28 days). It’s taken together with Vocabria (cabotegravir)
- Replacing a missed injection of Cabenuva (cabotegravir / rilpivirine): Your HIV specialist might prescribe rilpivirine for you to take for a short while if you’re getting Cabenuva injections for HIV but will miss an injection because of a schedule conflict (e.g., traveling). The typical dose of rilpivirine is 25 mg by mouth once a day with a meal and with Vocabria (cabotegravir). This combination is only meant to be taken for up to 2 months to replace missed injections
Is it safe for me to take rilpivirine?
rilpivirine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you take any medications that can greatly lower the amount of rilpivirine in your body, such as certain anti-seizure medications (e.g., carbamazepine (Tegretol)), certain antibiotics (e.g., rifampin (Rifadin)), more than a single dose of dexamethasone, or St. John’s wort
rilpivirine Common Side Effects
Common side effects of rilpivirine:
- Higher liver function tests
- Higher cholesterol levels
- Higher creatinine levels
- Feeling depressed
- Headache
- Trouble sleeping
- Rash
rilpivirine Serious Side Effects
Serious side effects are rare with rilpivirine. Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts and behaviors
- Serious allergic reactions: mouth sores; trouble breathing; rash; fever; swelling in your face, lips, or tongue
- Liver problems: upper right stomach pain, nausea, yellowing of the skin or whites of the eyes, dark urine
Effects of other drugs, drug classes and over-the-counter products on rilpivirine
The following medications may interact with rilpivirine:
- Consider alternatives to rilpivirine or rilpivirine PED when coadministered with drugs with a known risk of torsade de pointes
- rilpivirine and rilpivirine PED should not be used in combination with NNRTIs
- Coadministration of rilpivirine or rilpivirine PED with drugs that induce or inhibit CYP3A may affect the plasma concentrations of rilpivirine
- Coadministration of rilpivirine or rilpivirine PED with drugs that increase gastric pH may decrease plasma concentrations of rilpivirine
- Refer to the Full Prescribing Information for other drugs that should not be coadministered with rilpivirine or rilpivirine PED and for other drugs that may require a change in dose or regimen
Who makes rilpivirine?
Various FDA-approved generic manufacturers
Is rilpivirine safe in pregnancy?
It is not known if rilpivirine will harm your unborn baby. If you become pregnant while receiving rilpivirine, talk to your healthcare provider. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to
rilpivirine during pregnancy. Healthcare providers are encouraged to register patients by calling the Antiretroviral Pregnancy Registry (APR) 1-800-258-4263.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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