Used for Cancer

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

dostarlimab-gxly Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is dostarlimab-gxly available in?

What dosages is dostarlimab-gxly available in?

dostarlimab-gxly is available as a 500 mg/10 mL (50 mg/mL) injection for IV use.

What is dostarlimab-gxly used for?

What is dostarlimab-gxly used for?

  • dostarlimab-gxly is a monoclonal antibody that is used to treat endometrial cancer and Mismatch repair deficient recurrent or advanced solid tumors
How does dostarlimab-gxly work?

How does dostarlimab-gxly work?

dostarlimab-gxly is a type of immunotherapy called an immune checkpoint inhibitor. PD-1 is a type of checkpoint protein found on T cells, which are immune system cells that roam throughout the body looking for signs of disease or infection. PD-L1 is another checkpoint protein found on many healthy cells in the body. When PD-1 binds to PD-L1, it stops T cells from killing a cell. Still, some cancer cells have a lot of PD-L1 on their surface, which stops T cells from killing these cancer cells. An immune checkpoint inhibitor medicine like dostarlimab-gxly that stops PD-1 from binding to PD-L1 allows T cells to attack the cancer cells.

How do I take dostarlimab-gxly?

How do I take dostarlimab-gxly?

  • dostarlimab-gxly in combination with carboplatin and paclitaxel, for dMMR or MSI-H primary advanced or recurrent endometrial cancer: 500 mg every 3 weeks for 6 doses followed by 1,000 mg monotherapy every 6 weeks
  • dostarlimab-gxly, as a single agent, for dMMR recurrent or advancedendometrial cancer: 500 mg every 3 weeks for 4 doses followed by 1,000 mg every 6 weeks. (2.2)
  • dostarlimab-gxly, as a single agent, for dMMR recurrent or advanced solid tumors: 500 mg every 3 weeks for 4 doses followed by 1,000 mg every 6 weeks
Is it safe for me to take dostarlimab-gxly?

Is it safe for me to take dostarlimab-gxly?

dostarlimab-gxly is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

dostarlimab-gxly Common Side Effects

dostarlimab-gxly Common Side Effects

Common side effects of dostarlimab-gxly:

  • Rash
  • Diarrhea
  • Hypothyroidism
  • Hypertension
  • Decreased neutrophils, hemoglobin, lymphocytes and white blood cells
  • Increased glucose
  • Decreased sodium
  • Decreased platelets
dostarlimab-gxly Serious Side Effects

dostarlimab-gxly Serious Side Effects

Serious side effects are rare with dostarlimab-gxly. Call or see your healthcare provider right away if you develop any of the following:

  • Lung problems
  • Intestinal problems
  • Liver problems
  • Skin problems
  • Hormone gland problems
  • Kidney problems
Effects of other drugs, drug classes and over-the-counter products on dostarlimab-gxly

Effects of other drugs, drug classes and over-the-counter products on dostarlimab-gxly

  • There are no major drug interactions listed for dostarlimab-gxly. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes dostarlimab-gxly?

Who makes dostarlimab-gxly?

Various FDA-approved generic manufacturers

Is dostarlimab-gxly safe in pregnancy?

Is dostarlimab-gxly safe in pregnancy?

Based on its mechanism of action, dostarlimab-gxly can cause fetal harm when administered to a pregnant woman. If you can become pregnant, you should use effective contraception during treatment with dostarlimab-gxly and for 4 months after the last dose.


What to do if you missed your dostarlimab-gxly dose

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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