Key facts about Dolutegravir/Rilpivirine
What dosages is Dolutegravir/Rilpivirine available in?
Dolutegravir/Rilpivirine is available as an oral tablet that contains 50 mg of dolutegravir (equivalent to 52.6 mg dolutegravir sodium) and 25 mg of rilpivirine (equivalent to 27.5 mg rilpivirine hydrochloride).
What is Dolutegravir/Rilpivirine used for?
Dolutegravir/Rilpivirine is a combination antiretroviral (ARV) used to treat HIV in people who are well controlled on an HIV ARV regimen already and want to switch.
How does Dolutegravir/Rilpivirine work?
Dolutegravir/Rilpivirine contains 2 antiretroviral (ARV) medications:
- Dolutegravir is an integrase inhibitor and prevents HIV from inserting itself in your DNA (genetic material).
- Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It stops an important enzyme (reverse transcriptase) and blocks the HIV DNA-making process.
How do I take Dolutegravir/Rilpivirine?
The typical dose of Dolutegravir/Rilpivirine is one tablet by mouth once daily with a meal.
Is it safe for me to take Dolutegravir/Rilpivirine?
Dolutegravir/Rilpivirine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Previous hypersensitivity reaction to dolutegravir or rilpivirine
- Coadministration with dofetilide or medications that lower the level of rilpivirine in your body, such as proton pump inhibitors (PPIs), rifampin, or certain antiseizure medications
Dolutegravir/Rilpivirine Common Side Effects
Common side effects of Dolutegravir/Rilpivirine:
- Diarrhea
- Headache
- Nausea
Dolutegravir/Rilpivirine Serious Side Effects
Serious side effects are rare with Dolutegravir/Rilpivirine. Contact your healthcare provider immediately if you experience any of the following:
- Allergic reaction
- Liver damage
- Depression or mood changes
Effects of other drugs, drug classes and over-the-counter products on Dolutegravir/Rilpivirine
The following medications may interact with Dolutegravir/Rilpivirine:
- Other antiretroviral medications for the treatment of HIV-1 infection are not recommended
- Drugs that induce UGT1A1 or CYP3A4
- Medications that can cause Torsade de Pointes
Who makes Dolutegravir/Rilpivirine?
Various FDA-approved generic manufacturers
Is Dolutegravir/Rilpivirine safe in pregnancy?
It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you. There is a pregnancy registry for those who take Dolutegravir/Rilpivirine during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk with your healthcare provider about how you can take part in this registry.
