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Darunavir/Cobicistat is available as an oral tablet that contains 800 mg of darunavir and 150 mg of cobicistat.

• Darunavir/Cobicistat is a combination of 2 medications that are used in the treatment of HIV infection in adults and children weighing at least 88 pounds

Darunavir/Cobicistat is a combination of two medications:
Darunavir is a protease inhibitor, which means it blocks a protein called protease. Normally, protease helps process viral proteins so that HIV can infect healthy cells. By blocking protease from working, darunavir prevents the virus from making copies of itself and spreading. Cobicistat is a “booster” medication. It slows down your body from breaking down other HIV ARVs like darunavir. This “boosts” the levels of darunavir and other HIV ARVs in the body. It also makes them last longer in the body. This helps darunavir and other HIV ARVs work better to fight the infection.

• Darunavir/Cobicistat is typically taken as 1 tablet by mouth once daily with food

Darunavir/Cobicistat is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Darunavir/Cobicistat is contraindicated in patients receiving certain co-administered drugs for which altered plasma concentrations are associated with serious and/or life threatening events or loss of therapeutic effect.

Common side effects of Darunavir/Cobicistat:

• Diarrhea
• Nausea
• Stomach pain
• Vomiting
• Headache
• Rash

Serious side effects are rare with Darunavir/Cobicistat. Contact your healthcare provider immediately if you experience any of the following.

• Serious liver problems: nausea, vomiting, not feeling hungry, pain in the right side of the stomach, yellowing of the whites of the eyes or skin, dark-colored urine, light-colored stool
• Severe allergic or skin reactions: facial swelling, hives, rash, itchy skin, blistering or peeling of skin, body aches, trouble breathing, fever

The following medications may interact with Darunavir/Cobicistat:

• Co-administration of Darunavir/Cobicistat with other drugs can alter the concentration of other drugs and other drugs may alter the concentrations of darunavir or cobicistat. Consult the full prescribing information prior to and during treatment for potential drug interactions

Various FDA-approved generic manufacturers

Darunavir/Cobicistat is not recommended during pregnancy due to
substantially lower exposures of darunavir and cobicistat during pregnancy.

• Prezcobix