daratumumab
Used for Cancer
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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daratumumab Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is daratumumab available in?
daratumumab is available as a 100 mg/5 mL and 400 mg/20 mL injection for IV use.
What is daratumumab used for?
daratumumab is an anti-CD38 monoclonal antibody and is used for the following:
Multiple myeloma:
- Given alone or in combination with certain other medications for people who haven’t responded well to previous treatments
- Given in combination with certain medications (other medications differ for people who can and can’t receive a stem-cell transplant)
How does daratumumab work?
daratumumab is an anti-CD38 monoclonal antibody. It treats multiple myeloma by targeting a specific protein called CD38 on the cells’ surface. Many cells, including healthy cells, have this protein. But multiple myeloma cells just have more of them. By binding to this protein, daratumumab attacks and kills the cancer cells, and also signals to the immune system to do the same. As a result, multiple myeloma cells can’t grow and spread as well.
How do I take daratumumab?
- daratumumab is given as an infusion into the veins (IV) by a healthcare provider in a hospital or clinic setting. Your provider will determine your dose based on your body weight
- Adults: When daratumumab is given alone, the typical dose is 16 mg/kg once a week for 8 doses, then every 2 weeks for 8 doses, then every 4 weeks thereafter
- When daratumumab is given together with other anticancer medications, your provider will determine your dose and how often you receive it based on what medication combination you’re taking
Is it safe for me to take daratumumab?
daratumumab is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
daratumumab Common Side Effects
Common side effects of daratumumab:
- Lower white blood cell counts
- Lower platelet counts
- Infusion-related reactions
- Lower red blood cell counts
- Tiredness
- Nausea
- Back pain
- Cough
- Fever
- Upper respiratory tract infections
daratumumab Serious Side Effects
Serious side effects are rare with daratumumab. Contact your healthcare provider immediately if you experience any of the following.
- Serious reaction during infusion: fever, headache, stuffy nose, sore throat, cough, trouble breathing, fast heart beat, changes in blood pressure, chills, itching, rash, blurry or changes in vision
- Serious infections (from low white blood cell levels): fever, headache, sore throat, cough, body aches, chills, weakness, tiredness
Effects of other drugs, drug classes and over-the-counter products on daratumumab
- There are no major drug interactions listed for daratumumab. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes daratumumab?
Various FDA-approved generic manufacturers
Is daratumumab safe in pregnancy?
Based on the mechanism of action, daratumumab can cause fetal harm when administered to a pregnant woman. Women should use effective contraception during treatment with daratumumab and for 3 months after the last dose.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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