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crizanlizumab-tmca Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is crizanlizumab-tmca available in?

What dosages is crizanlizumab-tmca available in?

crizanlizumab-tmca is available as a 100 mg/10 mL (10 mg/mL) solution in a single-dose vial.

What is crizanlizumab-tmca used for?

What is crizanlizumab-tmca used for?

crizanlizumab-tmca is a monoclonal antibody that is used to lessen the number of vaso-occlusive crises (pain crises) in people aged 16 years and older with sickle cell disease (SCD).

How does crizanlizumab-tmca work?

How does crizanlizumab-tmca work?

crizanlizumab-tmca is a monoclonal antibody that binds to P-selectin, which is a sticky protein that normally plays a role in blocking blood flow. In people with sickle cell anemia, P-selectin gets activated when blood vessels are damaged by the sickled red blood cells. This causes your red blood cells, white blood cells, and platelets to stick together and block blood flow, which results in pain crises. By binding to P-selectin, crizanlizumab-tmca stops your blood cells from sticking together. This means your blood can flow better, which lowers the amount of pain crises.

How do I take crizanlizumab-tmca?

How do I take crizanlizumab-tmca?

crizanlizumab-tmca is only available as an intravenous (IV) infusion that’s administered by a healthcare provider. Your dose of crizanlizumab-tmca depends on your weight. In general, the typical dose is 5 mg/kg, given as an IV infusion over a period of 30 minutes, at Week 0, Week 2, and then every 4 weeks thereafter.

Is it safe for me to take crizanlizumab-tmca?

Is it safe for me to take crizanlizumab-tmca?

crizanlizumab-tmca is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

crizanlizumab-tmca Common Side Effects

crizanlizumab-tmca Common Side Effects

Common side effects of crizanlizumab-tmca:

  • Nausea
  • Joint pain
  • Back pain
  • Stomach pain
  • Fever
crizanlizumab-tmca Serious Side Effects

crizanlizumab-tmca Serious Side Effects

Serious side effects are rare with crizanlizumab-tmca. Contact your healthcare provider immediately if you experience any of the following. Infusion-related reactions: pain in different parts of your body, fever, chills, nausea, vomiting, dizziness, hives, difficulty breathing.

Effects of other drugs, drug classes and over-the-counter products on crizanlizumab-tmca

Effects of other drugs, drug classes and over-the-counter products on crizanlizumab-tmca

There are no major drug interactions listed for crizanlizumab-tmca. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Who makes crizanlizumab-tmca?

Who makes crizanlizumab-tmca?

Various FDA-approved generic manufacturers

Is crizanlizumab-tmca safe in pregnancy?

Is crizanlizumab-tmca safe in pregnancy?

Based on data from animal studies, crizanlizumab-tmca has the potential to cause fetal harm when administered to a pregnant
woman. crizanlizumab-tmca should only be used during pregnancy if the expected benefit to the patient justifies the potential risk to the


What to do if you missed your crizanlizumab-tmca dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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