ADAKVEO
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Manufactured by Novartis Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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ADAKVEO Uses, Side Effects, Interactions, Warnings & Dosing
What is ADAKVEO?
ADAKVEO is the brand name for crizanlizumab-tmca and is available as an IV infusion.
What dosages is ADAKVEO available in?
ADAKVEO is available as a 100 mg/10 mL (10 mg/mL) solution in a single-dose vial.
What is ADAKVEO used for?
ADAKVEO is a monoclonal antibody that is used to lessen the number of vaso-occlusive crises (pain crises) in people aged 16 years and older with sickle cell disease (SCD).
How does ADAKVEO work?
ADAKVEO is a monoclonal antibody that binds to P-selectin, which is a sticky protein that normally plays a role in blocking blood flow. In people with sickle cell anemia, P-selectin gets activated when blood vessels are damaged by the sickled red blood cells. This causes your red blood cells, white blood cells, and platelets to stick together and block blood flow, which results in pain crises. By binding to P-selectin, ADAKVEO stops your blood cells from sticking together. This means your blood can flow better, which lowers the amount of pain crises.
How do I take ADAKVEO?
ADAKVEO is only available as an intravenous (IV) infusion that’s administered by a healthcare provider. Your dose of ADAKVEO depends on your weight. In general, the typical dose is 5 mg/kg, given as an IV infusion over a period of 30 minutes, at Week 0, Week 2, and then every 4 weeks thereafter.
Is it safe for me to take ADAKVEO?
ADAKVEO is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
ADAKVEO Common Side Effects
Common side effects of ADAKVEO:
- Nausea
- Joint pain
- Back pain
- Stomach pain
- Fever
ADAKVEO Serious Side Effects
Serious side effects are rare with ADAKVEO. Contact your healthcare provider immediately if you experience any of the following. Infusion-related reactions: pain in different parts of your body, fever, chills, nausea, vomiting, dizziness, hives, difficulty breathing.
Effects of other drugs, drug classes and over-the-counter products on ADAKVEO
There are no major drug interactions listed for ADAKVEO. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Who makes ADAKVEO?
Novartis Pharmaceuticals
Is ADAKVEO safe in pregnancy?
Based on data from animal studies, ADAKVEO has the potential to cause fetal harm when administered to a pregnant
woman. ADAKVEO should only be used during pregnancy if the expected benefit to the patient justifies the potential risk to the
fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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