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Cabazitaxel is available as a 60 mg/1.5 mL single use vial.

Cabazitaxel is a microtubule inhibitor that is used to treat prostate cancer that has spread to other areas of the body (used in combination with prednisone).

Cabazitaxel is a type of anticancer medication called a microtubule inhibitor. It interferes with the way cells divide and multiply, especially in fast-growing cells, like cancer cells. When this happens, the cells can no longer divide and grow.

Your provider will calculate your dose of Cabazitaxel using your body surface area (BSA, in units of m2), which takes into account your body weight and height. The typical dose is 20 mg/m2 infused through the veins once every 3 weeks. In addition, you’ll also take prednisone 10 mg by mouth once daily throughout [drug] treatment. Your dose might be different if you have liver problems.

Cabazitaxel is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following.

• Neutrophil counts of ≤1,500/mm3.
• History of severe hypersensitivity to Cabazitaxel or polysorbate 80

Common side effects of Cabazitaxel:

• Low red blood cell count
• Low white blood cell count
• Low platelet count
• Fatigue
• Diarrhea
• Nausea
• Pain in bones, joints, and muscles
• Vomiting
• Constipation
• Weakness or lack of energy

Serious side effects are rare with Cabazitaxel. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reaction: rash, trouble breathing, or lightheadedness
• Serious infections: repeated fevers, chills, sweating, trouble breathing, cough, sore throat, severe diarrhea, stomach pain, vomiting, painful or frequent urination
• Lung problems: cough, trouble breathing, shortness of breath, chest pain
• Kidney problems: bloody urine, urinating less, or swelling
• Stomach problems: stomach pain or tenderness, constipation that can’t be relieved, diarrhea, or fever
• Stomach bleeds: throwing up blood, bloody or black and tarry stool (or change in the color of your stool)

The following medications may interact with Cabazitaxel:

• Use with caution in patients taking concomitant medicines that induce or inhibit CYP3A

Various FDA-approved generic manufacturers

Cabazitaxel can cause fetal harm when administered to a pregnant woman. Use only if the potential benefit to the
mother justifies the potential risk to the fetus.

• Jevtana