BRAFTOVI
Used for Cancer
NowPatient helps you obtain your BRAFTOVI prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Pfizer
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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BRAFTOVI key facts
What is BRAFTOVI?
BRAFTOVI is the brand name for encorafenib and is available as an oral capsule.
What dosages is BRAFTOVI available in?
BRAFTOVI is available as a 75 mg oral capsule.
What is BRAFTOVI used for?
BRAFTOVI is a BRAF inhibitor and is used for the following:
Melanoma with certain BRAF mutations that has spread (metastatic) or that can’t be removed by surgery, used with Mektovi (binimetinib) Colorectal cancer with a certain BRAF mutation that has spread (metastatic), used with Erbitux (cetuximab)
How does BRAFTOVI work?
BRAFTOVI is a kinase inhibitor known as a BRAF inhibitor. The BRAF protein is part of a whole chain of proteins that help cells (including cancer cells) grow. When the BRAF protein is mutated, the cancer grows uncontrollably and can spread more quickly. By blocking BRAF, BRAFTOVI helps stop tumor growth.
How do I take BRAFTOVI?
Melanoma: The typical dose is 450 mg (six 75 mg capsules) by mouth once daily. Colorectal cancer: The typical dose is 300 mg (four 75 mg capsules) by mouth once daily.
Your dose might differ depending on the other medications you might be taking and whether they can interact with BRAFTOVI
Is it safe for me to take BRAFTOVI?
BRAFTOVI is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
BRAFTOVI Common Side Effects
Common side effects of BRAFTOVI:
- Fatigue
- Nausea
- Lower red blood cells
- Vomiting
- Stomach pain
- Higher liver enzymes in blood
- Joint pain
- Lower white blood cell count
- Muscle pain
- Constipation
- Rash
- Headache
BRAFTOVI Serious Side Effects
Serious side effects are rare with BRAFTOVI. Contact your healthcare provider immediately if you experience any of the following.
- Bleeding: blood in stool, bleeding from rectum, sudden headache
- Changes in heart rhythm: lightheadedness, fainting, seizures, loss of consciousness
Effects of other drugs, drug classes and over-the-counter products on BRAFTOVI
The following medications may interact with BRAFTOVI:
- Strong or moderate CYP3A4 inhibitors: Avoid coadministration. If unavoidable, reduce BRAFTOVI dosage
- Strong CYP3A4 inducers: Avoid coadministration.
- Sensitive CYP3A4 substrates: Avoid coadministration with CYP3A4 substrates (including hormonal contraceptives) for which a decrease in plasma concentration may lead to reduced efficacy of the substrate
- Transporters: Dose reductions of drugs that are substrates of OATP1B1, OATP1B3, or BCRP may be required when used concomitantly with BRAFTOVI
Who makes BRAFTOVI?
Pfizer
Is BRAFTOVI safe in pregnancy?
BRAFTOVI can harm your unborn baby. Females who are able to become pregnant should use effective non-hormonal birth control (contraception) during treatment with BRAFTOVI and for 2 weeks after the last dose of BRAFTOVI. Birth control methods that contain hormones (such as birth control pills, injections or transdermal systems) may not work as well during treatment with BRAFTOVI. Talk to your healthcare provider about birth control methods that may be right for you during this time. Your healthcare provider will do a pregnancy test before you start taking BRAFTOVI. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with BRAFTOVI.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my BRAFTOVI prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your BRAFTOVI prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient BRAFTOVI savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient BRAFTOVI savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for BRAFTOVI | Canadian Prescription Savings* for BRAFTOVI | BRAFTOVI Drug Coupon* | BRAFTOVI Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of BRAFTOVI?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for BRAFTOVI | Canadian Prescription Savings* for BRAFTOVI | BRAFTOVI Drug Coupon* | BRAFTOVI Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the BRAFTOVI savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the BRAFTOVI drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for BRAFTOVI, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the BRAFTOVI prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, BRAFTOVI is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed BRAFTOVI for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the BRAFTOVI prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the BRAFTOVI prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for BRAFTOVI
If you are having trouble paying for your BRAFTOVI medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for BRAFTOVI you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- BRAFTOVI is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers BRAFTOVI
- If BRAFTOVI is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for BRAFTOVI
If you are having trouble paying for your BRAFTOVI medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for BRAFTOVI you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers BRAFTOVI
- If BRAFTOVI is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for BRAFTOVI
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your BRAFTOVI treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for BRAFTOVI you will need to meet the following criteria:
- You must be currently insured and have coverage for BRAFTOVI
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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