Used for Cancer

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Manufactured by various FDA-approved generic manufacturers.

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

encorafenib Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is encorafenib available in?

What dosages is encorafenib available in?

encorafenib is available as a 75 mg oral capsule.

What is encorafenib used for?

What is encorafenib used for?

encorafenib is a BRAF inhibitor and is used for the following:
Melanoma with certain BRAF mutations that has spread (metastatic) or that can’t be removed by surgery, used with Mektovi (binimetinib) Colorectal cancer with a certain BRAF mutation that has spread (metastatic), used with Erbitux (cetuximab)

How does encorafenib work?

How does encorafenib work?

encorafenib is a kinase inhibitor known as a BRAF inhibitor. The BRAF protein is part of a whole chain of proteins that help cells (including cancer cells) grow. When the BRAF protein is mutated, the cancer grows uncontrollably and can spread more quickly. By blocking BRAF, encorafenib helps stop tumor growth.

How do I take encorafenib?

How do I take encorafenib?

Melanoma: The typical dose is 450 mg (six 75 mg capsules) by mouth once daily. Colorectal cancer: The typical dose is 300 mg (four 75 mg capsules) by mouth once daily.

Your dose might differ depending on the other medications you might be taking and whether they can interact with encorafenib

Is it safe for me to take encorafenib?

Is it safe for me to take encorafenib?

encorafenib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

encorafenib Common Side Effects

encorafenib Common Side Effects

Common side effects of encorafenib:

  • Fatigue
  • Nausea
  • Lower red blood cells
  • Vomiting
  • Stomach pain
  • Higher liver enzymes in blood
  • Joint pain
  • Lower white blood cell count
  • Muscle pain
  • Constipation
  • Rash
  • Headache
encorafenib Serious Side Effects

encorafenib Serious Side Effects

Serious side effects are rare with encorafenib. Contact your healthcare provider immediately if you experience any of the following.

  • Bleeding: blood in stool, bleeding from rectum, sudden headache
  • Changes in heart rhythm: lightheadedness, fainting, seizures, loss of consciousness
Effects of other drugs, drug classes and over-the-counter products on encorafenib

Effects of other drugs, drug classes and over-the-counter products on encorafenib

The following medications may interact with encorafenib:

  • Strong or moderate CYP3A4 inhibitors: Avoid coadministration. If unavoidable, reduce encorafenib dosage
  • Strong CYP3A4 inducers: Avoid coadministration.
  • Sensitive CYP3A4 substrates: Avoid coadministration with CYP3A4 substrates (including hormonal contraceptives) for which a decrease in plasma concentration may lead to reduced efficacy of the substrate
  • Transporters: Dose reductions of drugs that are substrates of OATP1B1, OATP1B3, or BCRP may be required when used concomitantly with encorafenib
Who makes encorafenib?

Who makes encorafenib?

Various FDA-approved generic manufacturers

Is encorafenib safe in pregnancy?

Is encorafenib safe in pregnancy?

encorafenib can harm your unborn baby. Females who are able to become pregnant should use effective non-hormonal birth control (contraception) during treatment with encorafenib and for 2 weeks after the last dose of encorafenib. Birth control methods that contain hormones (such as birth control pills, injections or transdermal systems) may not work as well during treatment with encorafenib. Talk to your healthcare provider about birth control methods that may be right for you during this time. Your healthcare provider will do a pregnancy test before you start taking encorafenib. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with encorafenib.


What to do if you missed your encorafenib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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