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Bendamustine is available in a multiple-dose vial that contains 100 mg/4 mL (25 mg/mL) of Bendamustine.

Bendamustine is used for treatment of patients with chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL).

Bendamustine is an alkylating drug that works by slowing down the growth of cancer cells.

Bendamustine is dosed as follows:

For CLL:

• 100 mg/m2 is infused intravenously over 10 minutes on Days 1 and 2 of a 28-day cycle, for up to 6 cycles.

For NHL:

• 120 mg/m2 is infused intravenously over 10 minutes on Days 1 and 2 of a 21-day cycle, for up to 8 cycles.

Bendamustine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a history of a hypersensitivity reaction to Bendamustine, polyethylene glycol 400, propylene glycol, or monothioglycerol.

Common side effects of Bendamustine:

• Nausea
• Fever
• Fatigue
• Low blood cell counts
• Diarrhea
• Constipation
• Weight loss
• Cough
• Headache
• Rash
• Shortness of breath

Serious side effects are rare with . Contact your healthcare provider immediately if you experience any of the following:

• Allergic reaction
• Severe skin reaction
• Tumor lysis syndrome (a rapid breakdown of cancer cells that can lead to kidney failure)
• Extravasation injury (leaking from the vein into surrounding tissue)
• Liver damage

The following medications may interact with Bendamustine:

• CYP1A2 inducers or inhibitors

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Bendeka