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Avalglucosidase Alfa-Ngpt is available as 100 mg of Avalglucosidase Alfa-Ngpt in a single-dose vial.

Avalglucosidase Alfa-Ngpt is a type of enzyme replacement therapy used to treat late-onset Pompe disease (LOPD).

Avalglucosidase Alfa-Ngpt is a hydrolytic lysosomal glycogen-specific enzyme. In Pompe disease, you’re missing an enzyme in your body called acid alpha-glucosidase (GAA). Without this enzyme, your body isn’t able to break down glycogen into sugar to use as a source of energy. Avalglucosidase Alfa-Ngpt serves as a replacement for GAA, which allows your body to convert glycogen into sugar to use for energy.

The typical dose of Avalglucosidase Alfa-Ngpt is based on your body weight and will be calculated by your provider. It will then be given as an IV infusion every 2 weeks.

Avalglucosidase Alfa-Ngpt is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Avalglucosidase Alfa-Ngpt:

• Headache
• Fatigue
• Diarrhea
• Nausea
• Joint pain
• Muscle pain
• Dizziness
• Itchy skin
• Vomiting
• Shortness of breath or trouble breathing
• Numb or tingling sensation
• Skin redness
• Rash

Serious side effects are rare with Avalglucosidase Alfa-Ngpt. Contact your healthcare provider immediately if you experience any of the following:

• Allergic reactions: hives, rash, blisters, skin reddening, swelling of the lips or tongue, difficulty breathing

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Nexviazyme