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Angeliq is the brand name for drospirenone and estradiol and is available as an oral tablet.

Angeliq is available as an oral tablet that contains 0.25 mg drospirenone/0.5 mg estradiol or 0.5 mg drospirenone/1 mg estradiol.

Angeliq is a type of hormone replacement therapy that is used to treat:

• Moderate-to-severe vasomotor symptoms (VMS) of menopause, like hot flashes and night sweats
• Moderate-to-severe symptoms of vulvar and vaginal atrophy, like vaginal dryness and irritation

Angeliq replaces estrogen and progesterone hormones during menopause:

• Estradiol replaces the estrogen that your body loses during menopause, which lessens the symptoms of vaginal dryness and hot flashes.
• Drospirenone is a progestin. It acts like progesterone and helps balance the effect of estrogen on the growth of your uterine lining.

Angeliq is typically taken by mouth once daily.

Angeliq is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Abnormal vaginal bleeding that your gynecologist doesn’t know about or you haven’t gone to them about
• Currently have or have had breast cancer
• Estrogen-dependent cancers (e.g., endometrial cancer, ovarian cancer)
• High risk for developing a blood clot
• History of blood clots, stroke, or heart attack
• Have a bleeding disorder
• Kidney problems
• Liver problems
• Currently have Addison’s disease or a disease of your adrenal glands
• Have had your uterus (womb) removed

Common side effects of Angeliq:

• Breast pain or discomfort
• Vaginal bleeding
• Belly pain
• Headache
• Nausea

Serious side effects are rare with Angeliq. Contact your healthcare provider immediately if you experience any of the following:

• Heart attack: chest pain, belly discomfort, sweating, nausea, dizziness
• Stroke: sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, difficulty walking
• Deep vein thrombosis (blood clot in the leg): leg cramp, swelling, pain, muscle tightness
• Pulmonary embolism (blood clot in the lung): cough, chest pain, trouble breathing, racing heart
• Liver or gallbladder problems: yellowing of the skin or the whites of the eyes, tiredness, pain in the right upper stomach, dark urine
• Unusual vaginal bleeding, vaginal discharge, or pelvic pain

The following medications may interact with Angeliq:

• Inducers and inhibitors of CYP3A4 may affect estrogen drug metabolism and
• Decrease or increase the estrogen plasma concentration.
• Medications that increase your potassium levels.

Bayer Healthcare

Angeliq should not be used during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant.

• Drospirenone And Estradiol